Evidence map›Paper›PMID 38194919›Full record

ArticleCurrent biology : CB2024

Light evokes stereotyped global brain dynamics in Caenorhabditis elegans.

Wayan Gauthey, Francesco Randi, Anuj K Sharma, Sandeep Kumar, Andrew M Leifer

Open access · hybridAbstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Current biology : CB, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Symmetries and synchronization from whole-neural activity in theProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Wayan GautheyPrinceton Neuroscience Institute, Princeton University, Princeton, NJ 08544, USA.
Francesco RandiDepartment of Physics, Princeton University, Princeton, NJ 08544, USA.
Anuj K SharmaDepartment of Physics, Princeton University, Princeton, NJ 08544, USA.
Sandeep KumarPrinceton Neuroscience Institute, Princeton University, Princeton, NJ 08544, USA.
Andrew M LeiferPrinceton Neuroscience Institute, Princeton University, Princeton, NJ 08544, USA; Department of Physics, Princeton University, Princeton, NJ 08544, USA. Electronic address: leifer@princeton.edu.
Princeton University · US

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
Probing Brain-wide Functional Connectivity During BehaviorDP2NS116768 · NINDS · PRINCETON UNIVERSITY · PI LEIFER, ANDREW MICHAEL · 2019 to 2019
$2.4M
NIH HHS P40 OD010440NINDS NIH HHS DP2 NS116768
6 · The paper itself

Abstract

Stereotyped oscillations in population neural activity recordings from immobilized Caenorhabditis elegans have garnered interest for their striking low dimensionality and their evocative state-space trajectories or manifolds. Previously these oscillations have been interpreted as intrinsically driven global motor commands. Here we test whether these oscillations are intrinsic. We show that similar oscillations are evoked by high-intensity blue light commonly used for calcium imaging. Oscillations are reduced or absent and have a lower frequency when a longer imaging wavelength is used. Under the original blue light illumination, oscillations are reduced or have a lower frequency in animals that lack GUR-3, an endogenous light- and hydrogen-peroxide-sensitive gustatory receptor. Additional experiments with hydrogen peroxide are consistent with GUR-3's involvement. We therefore propose that blue light evokes global oscillations in part through the creation of reactive oxygen species that activate the hydrogen-peroxide-sensing receptor GUR-3.

Indexed as

BrainCaenorhabditis elegansAnimalsBlue LightHydrogenHydrogen PeroxidePeroxidesHydrogenHydrogen PeroxidePeroxides

Identifiers

PMID38194919
PMCPMC10783800
OpenAlexW4390672773

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.