Evidence map›Paper›PMID 38194456›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

A structurally precise mechanism links an epilepsy-associated

Jerome Clatot, Christopher B Currin, Qiansheng Liang, Tanadet Pipatpolkai, Shavonne L Massey, Ingo Helbig, Lucie Delemotte, Tim P Vogels, Manuel Covarrubias, Ethan M Goldberg

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 19 citations in OpenAlex.

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  12. A structurally precise mechanism links an epilepsy-associatedProceedings of the National Academy of Sciences of the United States of America · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Jerome Clatot *Division of Neurology, The Children's Hospital of Philadelphia, Philadelphia, PA 19104.
Christopher B Currin *The Institute of Science and Technology Austria, Klosterneuburg 3400, Austria.
Qiansheng LiangDepartment of Neuroscience and Vickie and Jack Farber Institute for Neuroscience, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA 19107.ORCID 0009-0009-0856-1957
Tanadet PipatpolkaiDepartment of Applied Physics, Science for Life Laboratory, Royal Institute of Technology, Solna SE-171 21, Sweden.
Shavonne L MasseyDivision of Neurology, The Children's Hospital of Philadelphia, Philadelphia, PA 19104.
Ingo HelbigDivision of Neurology, The Children's Hospital of Philadelphia, Philadelphia, PA 19104.
Lucie DelemotteDepartment of Applied Physics, Science for Life Laboratory, Royal Institute of Technology, Solna SE-171 21, Sweden.ORCID 0000-0002-0828-3899
Tim P VogelsThe Institute of Science and Technology Austria, Klosterneuburg 3400, Austria.ORCID 0000-0003-3295-6181
Manuel CovarrubiasDepartment of Neuroscience and Vickie and Jack Farber Institute for Neuroscience, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA 19107.
Ethan M GoldbergDivision of Neurology, The Children's Hospital of Philadelphia, Philadelphia, PA 19104.ORCID 0000-0002-7404-735X
Children's Hospital of Philadelphia · USInstitute of Science and Technology Austria · ATScience for Life Laboratory · SEThomas Jefferson University · US

Funding

Project 3 - Development and investigation of murine models of channelopathy-associated epilepsyU54NS108874 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GEORGE, ALFRED L. · 2018 to 2022
$12.1M
A computational phenotyping approach to characterize neurogenetic disordersR01NS131512 · NINDS · CHILDREN'S HOSP OF PHILADELPHIA · PI Ingo Helbig · 2023 to 2026
$2.8M
Mechanistically-oriented therapy for a progressive myoclonus epilepsyR01NS122887 · NINDS · CHILDREN'S HOSP OF PHILADELPHIA · PI ETHAN M GOLDBERG · 2022 to 2026
$2.5M
Joint analysis of genomic and electronic medical record data to assess outcomes and drug response in pediatric epilepsiesK02NS112600 · NINDS · CHILDREN'S HOSP OF PHILADELPHIA · PI HELBIG, INGO · 2020 to 2024
$963k
NINDS NIH HHS K02 NS112600NINDS NIH HHS R01 NS122887NINDS NIH HHS R01 NS131512NINDS NIH HHS U54 NS108874
6 · The paper itself

Abstract

De novo heterozygous variants in

Indexed as

EpilepsyShaw Potassium ChannelsCerebral CortexHumansInterneuronsMutationKCNC2 protein, humanShaw Potassium ChannelsepilepsyKCNC2Kv3.2neurogeneticspotassium channels

Identifiers

PMID38194456
PMCPMC10801864
OpenAlexW4390744325

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.