Evidence map›Paper›PMID 38194362›Full record

ArticleACS synthetic biology2024

High-Yield Lasso Peptide Production in a

Hannah N Fernandez, Ashley M Kretsch, Sylvia Kunakom, Adjo E Kadjo, Douglas A Mitchell, Alessandra S Eustáquio

Open access · greenAbstract read
In one paragraph

Article in ACS synthetic biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
9.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Evolution-Guided Discovery of Antimycobacterial Triculamin-Like Lasso Peptides.Angewandte Chemie (International ed. in English) · 2025
    Article
  7. Article
  8. Evaluation of vectors for gene expression inApplied and environmental microbiology · 2025
    Article
  9. Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Hannah N FernandezDepartment of Pharmaceutical Sciences and Center for Biomolecular Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60607, United States.
Ashley M KretschDepartment of Chemistry and Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.
Sylvia KunakomDepartment of Pharmaceutical Sciences and Center for Biomolecular Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60607, United States.
Adjo E KadjoDepartment of Pharmaceutical Sciences and Center for Biomolecular Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60607, United States.
Douglas A MitchellDepartment of Chemistry and Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.ORCID 0000-0002-9564-0953
Alessandra S EustáquioDepartment of Pharmaceutical Sciences and Center for Biomolecular Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60607, United States.ORCID 0000-0002-7852-7844
University of Illinois Chicago · USUniversity of Illinois Urbana-Champaign · US

Funding

Development of a Bacterial Host for Natural Product Discovery and ProductionR01GM129344 · NIGMS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI EUSTAQUIO, ALESSANDRA S · 2020 to 2023
$1.5M
Uniquely constrained peptides for modulating TNF receptor activityF32GM145122 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI KRETSCH, ASHLEY M. · 2022 to 2022
$68k
NIGMS NIH HHS F32 GM145122NIGMS NIH HHS R01 GM129344
6 · The paper itself

Abstract

The knotted configuration of lasso peptides confers thermal stability and proteolytic resistance, addressing two shortcomings of peptide-based drugs. However, low isolation yields hinder the discovery and development of lasso peptides. While testing

Indexed as

BurkholderiaDNA Copy Number VariationsEscherichia coliPeptidesPlasmidsPeptidesbacteriaBurkholderiaceaeheterologous expressionlasso peptidenatural productRiPPsecondary metabolite

Identifiers

PMID38194362
PMCPMC10947786
OpenAlexW4391035950

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.