Evidence map›Paper›PMID 38194343›Full record

ArticleCell reports2024

Ventral pallidum neurons projecting to the ventral tegmental area reinforce but do not invigorate reward-seeking behavior.

Dakota Palmer, Christelle A Cayton, Alexandra Scott, Iris Lin, Bailey Newell, Anika Paulson, Morgan Weberg, Jocelyn M Richard

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 9 citations in OpenAlex.

  1. Ventral pallidal GABAergic neurons control hedonic feeding and obesity.bioRxiv : the preprint server for biology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Dakota PalmerGraduate Program in Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA; Medical Discovery Team on Addiction, University of Minnesota, Minneapolis, MN 55455, USA.
Christelle A CaytonMedical Discovery Team on Addiction, University of Minnesota, Minneapolis, MN 55455, USA; Department of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA.
Alexandra ScottMedical Discovery Team on Addiction, University of Minnesota, Minneapolis, MN 55455, USA; Department of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA.
Iris LinMedical Discovery Team on Addiction, University of Minnesota, Minneapolis, MN 55455, USA; Department of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA.
Bailey NewellMedical Discovery Team on Addiction, University of Minnesota, Minneapolis, MN 55455, USA; Department of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA.
Anika PaulsonMedical Discovery Team on Addiction, University of Minnesota, Minneapolis, MN 55455, USA; Department of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA.
Morgan WebergDepartment of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA.
Jocelyn M RichardMedical Discovery Team on Addiction, University of Minnesota, Minneapolis, MN 55455, USA; Department of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address: richardj@umn.edu.
University of Minnesota · US

Funding

Viral Innovation CoreP30DA048742 · NIDA · UNIVERSITY OF MINNESOTA · PI Anna Zilverstand · 2020 to 2026
$19.0M
Predoctoral Training of NeuroscientistsT32NS105604 · NINDS · UNIVERSITY OF MINNESOTA · PI A DAVID REDISH · 2018 to 2026
$3.5M
Neural basis of incentive and expected value representationsR01DA053208 · NIDA · UNIVERSITY OF MINNESOTA · PI Jocelyn M Richard · 2022 to 2026
$1.7M
Dissociating Invigoration and Reinforcement by GABAergic Ventral Pallidum Projections to the Ventral Tegmental Area During Cue-Elicited Reward-SeekingF31DA055442 · NIDA · UNIVERSITY OF MINNESOTA · PI PALMER, DAKOTA · 2022 to 2023
$49k
NIDA NIH HHS F31 DA055442NIDA NIH HHS P30 DA048742NIDA NIH HHS R01 DA053208NINDS NIH HHS T32 NS105604
6 · The paper itself

Abstract

Reward-predictive cues acquire motivating and reinforcing properties that contribute to the escalation and relapse of drug use in addiction. The ventral pallidum (VP) and ventral tegmental area (VTA) are two key nodes in brain reward circuitry implicated in addiction and cue-driven behavior. In the current study, we use in vivo fiber photometry and optogenetics to record from and manipulate VP→VTA in rats performing a discriminative stimulus task to determine the role these neurons play in invigoration and reinforcement by reward cues. We find that VP→VTA neurons are active during reward consumption and that optogenetic stimulation of these neurons biases choice behavior and is reinforcing. Critically, we find no encoding of reward-seeking vigor, and optogenetic stimulation does not enhance the probability or vigor of reward seeking in response to cues. Our results suggest that VP→VTA activity is more important for reinforcement than for invigoration of reward seeking by cues.

Indexed as

Basal ForebrainVentral Tegmental AreaAnimalsCuesNeuronsRatsReinforcement, PsychologyRewardCP: Cell biologyCP: Neurosciencecuesmotivationreinforcementrewardventral pallidumventral tegmental area

Identifiers

PMID38194343
PMCPMC10865898
OpenAlexW4390669449

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.