Evidence map›Paper›PMID 38194067›Full record

ArticleBulletin of experimental biology and medicine2023

Expression of GAD65/67 and VGLUT2 in Mediobasal Nuclei of Rat Hypothalamus during Aging.

P A Anfimova, L G Pankrasheva, A I Emanuilov, K Yu Moiseev, P M Maslyukov

Abstract read
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Article in Bulletin of experimental biology and medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

P A AnfimovaYaroslavl State Medical University, Ministry of Health of the Russian Federation, Yaroslavl, Russia.
L G PankrashevaYaroslavl State Medical University, Ministry of Health of the Russian Federation, Yaroslavl, Russia.
A I EmanuilovYaroslavl State Medical University, Ministry of Health of the Russian Federation, Yaroslavl, Russia.
K Yu MoiseevYaroslavl State Medical University, Ministry of Health of the Russian Federation, Yaroslavl, Russia.
P M MaslyukovYaroslavl State Medical University, Ministry of Health of the Russian Federation, Yaroslavl, Russia. mpm@ysmu.ru.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The expression of glutamate decarboxylase GAD65/67, an enzyme of GABA synthesis, and vesicular glutamate transporter 2 (VGLUT2) in the arcuate, dorsomedial, and ventromedial nuclei of the hypothalamus of young (3 months), adult (12 months), and old male rats (24 months) was studied by Western blotting. In old rats, an increase in the expression of GAD65/67 in the arcuate and dorsomedial, VGLUT2 in the arcuate, dorsomedial, and ventromedial nuclei was observed. Thus, an increase in opposite processes of inhibition and excitation is observed in the hypothalamic nuclei during aging.

Indexed as

HypothalamusNeuronsAgingAnimalsGlutamate DecarboxylaseMaleRatsVesicular Glutamate Transport Protein 2Glutamate Decarboxylaseglutamate decarboxylase 1glutamate decarboxylase 2Slc17a6 protein, ratVesicular Glutamate Transport Protein 2ageingGAD65/67hypothalamusVGLUT2Western blotting

Identifiers

PMID38194067

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.