Selective Accumulation of Poly(Lactic-Co-Glycolic Acid) Nanoparticles in Endotheliocytes and Mesenchymal Stromal Cells Cultured as Mixed-Cell Spheroids.

G E Leonov, I V Vakhrushev, V D Novikova, V V Burunova, T S Kovshova, Yu A Malinovskaya, K N Yarygin

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Article in Bulletin of experimental biology and medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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Authors and funding

7 authors at 2 institutions in 1 country.

G E LeonovV. N. Orekhovich Research Institute of Biomedical Chemistry, Moscow, Russia.

I V VakhrushevV. N. Orekhovich Research Institute of Biomedical Chemistry, Moscow, Russia.

V D NovikovaV. N. Orekhovich Research Institute of Biomedical Chemistry, Moscow, Russia.

V V BurunovaV. N. Orekhovich Research Institute of Biomedical Chemistry, Moscow, Russia.

T S KovshovaMendeleev University of Chemical Technology of Russia, Moscow, Russia.

Yu A MalinovskayaMendeleev University of Chemical Technology of Russia, Moscow, Russia.

K N YaryginV. N. Orekhovich Research Institute of Biomedical Chemistry, Moscow, Russia.

Institute of Biomedical Chemistry · RUD. Mendeleyev University of Chemical Technology of Russia · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The use of drug-loaded nanoparticles is an actively developed approach in targeted cancer therapy. Prevascularized spheroids generated from mesenchymal stem cells and endotheliocytes are considered as a model to evaluate the tropism of therapeutic nanoparticles to a specific tissue. Nanoparticles based on co-polymer of lactic and glycolic acids (poly(lactic-co-glycolic acid; PLGA) labeled with cyanine dye (Cy5) were incubated with prevascularized spheroids, and the rate of their penetration and their distribution in the spheroid-forming cells were evaluated. Endotheliocytes more intensively accumulated nanoparticles than mesenchymal stem cells: the number of nanoparticles in mixed-cell spheroids of mesenchymal stem cells and endotheliocytes was greater than in spheroids built solely of mesenchymal stem cells by 5±1.2 times. The developed 3D in vitro cell model provides a low-cost way to assess tissue tropism of therapeutic nanoparticles under conditions closer to natural in comparison with 2D culture.

Indexed as

Mesenchymal Stem CellsNanoparticlesCells, CulturedGlycolsLactic AcidPolyglycolic AcidPolylactic Acid-Polyglycolic Acid CopolymerGlycolsLactic AcidPolyglycolic AcidPolylactic Acid-Polyglycolic Acid Copolymercell spheroidsmesenchymal stem cellsnanoparticlesPLGA

Identifiers

PMID38194063

DOI10.3390/biology11010018

OpenAlexW4390779306

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.