Evidence map›Paper›PMID 38194042›Full record

ArticleOdontology2024

Effects of mineral trioxide aggregate and methyl sulfonyl methane on pulp exposure via RUNX2 and RANKL pathways.

Altar Ateş, Ayca Kurt, Tolga Mercantepe

Abstract read
PubMed Publisher
In one paragraph

Article in Odontology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.5field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Altar AteşDepartment of Pediatric Dentistry, Faculty of Dentistry, Recep Tayyip Erdogan University, 53100, Rize, Turkey.
Ayca KurtDepartment of Pediatric Dentistry, Faculty of Dentistry, Recep Tayyip Erdogan University, 53100, Rize, Turkey. ayca.kurt@erdogan.edu.tr.ORCID http://orcid.org/0000-0003-4762-7495
Tolga MercantepeDepartment of Histology and Embryology, Faculty of Medicine, Recep Tayyip Erdogan University, 53100, Rize, Turkey.
Recep Tayyip Erdoğan University · TR

Funding

Recep Tayyip Erdogan Üniversitesi TDH-2022-1383
6 · The paper itself

Abstract

The aim of this study was to determine the therapeutic effects of mineral trioxide aggregate (MTA) and methyl sulfonyl methane (MSM) on pulp damage due to pulp exposure through the RUNX2 and RANKL pathways. Seventy-two male Sprague-Dawley rats aged 4-6 months and weighing 250-300 g were divided into healthy, control, MTA, and MSM groups. After experimental applications, all rats at 2, 4, and 8 weeks were killed anesthetically with xylazine hydrochloride (Rompun, Bayer) 30 mg/kg and ketamine hydrochloride (Ketalar, Pfizer) 50 mg/kg injections (i.p.). We observed that necrotic odontoblasts, edema, inflammation, and vascular congestion findings were reduced from week 2 to week 8 in the MSM treatment group after pulp capping compared to the control group and MTA group. Similarly, we found a decrease in RUNX2 and RANKL levels in the MSM application group compared to the control and MTA groups (p < 0.05). MSM material has shown therapeutic effects on pulp capping treatment-induced pulp injury via increased RUNX2 ve RANKL expression.

Indexed as

Aluminum CompoundsCalcium CompoundsCore Binding Factor Alpha 1 SubunitDrug CombinationsOxidesRANK LigandRats, Sprague-DawleySilicatesAnimalsDental Pulp ExposureDimethyl SulfoxideMalePulp Capping and Pulpectomy AgentsRatsSulfonesAluminum CompoundsCalcium CompoundsCore Binding Factor Alpha 1 Subunitdimethyl sulfoneDimethyl SulfoxideDrug Combinationsmineral trioxide aggregateOxidesPulp Capping and Pulpectomy AgentsRANK LigandRunx2 protein, ratSilicatesSulfonesAnimal modelConcentrated growth factorInflammatory responseMineral trioxide aggregatePulpotomy

Identifiers

PMID38194042
OpenAlexW4390779355

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.