Evidence map›Paper›PMID 38193927›Full record

ReviewACS nano2024

Functionalized Nanomaterials Capable of Crossing the Blood-Brain Barrier.

Shuai Zha, Haitao Liu, Hengde Li, Haolan Li, Ka-Leung Wong, Angelo Homayoun All

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in ACS nano, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 164 papers.

0numbers the graph read from it
0cells of the map it votes in
164citing papers in PubMed
64.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

164 citing papers in PubMed, 262 citations in OpenAlex.

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104 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Shuai ZhaHubei University of Chinese Medicine, School of Laboratory Medicine, 16 Huangjia Lake West Road, Wuhan 430065, China.
Haitao LiuHong Kong Baptist University, Department of Chemistry, Ho Sin Hang Campus, 224 Waterloo Road, Kowloon, Hong Kong SAR 999077, China.
Hengde LiHong Kong Baptist University, Department of Chemistry, Ho Sin Hang Campus, 224 Waterloo Road, Kowloon, Hong Kong SAR 999077, China.
Haolan LiDalian University of Technology School of Chemical Engineering, Lingshui Street, Ganjingzi District, Dalian 116024, China.
Ka-Leung WongThe Hong Kong Polytechnic University Department of Applied Biology and Chemical Technology, Building Y815, 11 Yuk Choi Road, Hung Hom, Kowloon, Hong Kong SAR 999077, China.
Angelo Homayoun AllHong Kong Baptist University, Department of Chemistry, Ho Sin Hang Campus, 224 Waterloo Road, Kowloon, Hong Kong SAR 999077, China.ORCID 0000-0002-7086-2170
Hong Kong Baptist University · HKHong Kong Polytechnic University · HKHubei University of Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The blood-brain barrier (BBB) is a specialized semipermeable structure that highly regulates exchanges between the central nervous system parenchyma and blood vessels. Thus, the BBB also prevents the passage of various forms of therapeutic agents, nanocarriers, and their cargos. Recently, many multidisciplinary studies focus on developing cargo-loaded nanoparticles (NPs) to overcome these challenges, which are emerging as safe and effective vehicles in neurotheranostics. In this Review, first we introduce the anatomical structure and physiological functions of the BBB. Second, we present the endogenous and exogenous transport mechanisms by which NPs cross the BBB. We report various forms of nanomaterials, carriers, and their cargos, with their detailed BBB uptake and permeability characteristics. Third, we describe the effect of regulating the size, shape, charge, and surface ligands of NPs that affect their BBB permeability, which can be exploited to enhance and promote neurotheranostics. We classify typical functionalized nanomaterials developed for BBB crossing. Fourth, we provide a comprehensive review of the recent progress in developing functional polymeric nanomaterials for applications in multimodal bioimaging, therapeutics, and drug delivery. Finally, we conclude by discussing existing challenges, directions, and future perspectives in employing functionalized nanomaterials for BBB crossing.

Indexed as

NanoparticlesNanostructuresBiological TransportBlood-Brain BarrierBrainDrug Delivery Systemsabsorptive-mediated transcytosisBBB crossingBBB receptor-mediated endocytosisbrain deliverycentral nervous system deliveryfunctionalized nanomaterialsneurotheranosticsnoninvasive BBB cargo deliveryreceptor-mediated transcytosis

Identifiers

PMID38193927
PMCPMC10811692
OpenAlexW4390726995

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.