Evidence map›Paper›PMID 38193728›Full record

ArticlemBio2024

Casein kinase 2 complex: a central regulator of multiple pathobiological signaling pathways in

Yeseul Choi, Seong-Ryong Yu, Yujin Lee, Ann-Yae Na, Sangkyu Lee, Joseph Heitman, Ran Seo, Han-Seung Lee, Jong-Seung Lee, Yong-Sun Bahn

Open access · goldAbstract read
In one paragraph

Article in mBio, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Insights from Mass Spectrometry-Based Proteomics onJournal of fungi (Basel, Switzerland) · 2025
    Review
  8. Article
  9. Pleiotropic roles of LAMMER kinase, Lkh1 in stress responses and virulence ofFrontiers in cellular and infection microbiology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Yeseul ChoiDepartment of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul, South Korea.ORCID 0000-0002-9369-902X
Seong-Ryong YuDepartment of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul, South Korea.ORCID 0000-0003-0025-3860
Yujin LeeDepartment of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul, South Korea.ORCID 0000-0001-6991-0967
Ann-Yae NaSchool of Pharmacy, Sungkyunkwan University, Suwon, South Korea.ORCID 0000-0003-0089-3817
Sangkyu LeeSchool of Pharmacy, Sungkyunkwan University, Suwon, South Korea.ORCID 0000-0001-5343-701X
Joseph HeitmanDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, USA.ORCID 0000-0001-6369-5995
Ran SeoAmtixBio Co., Ltd., Hanam-si, Gyeonggi-do, South Korea.ORCID 0009-0001-1737-686X
Han-Seung LeeAmtixBio Co., Ltd., Hanam-si, Gyeonggi-do, South Korea.ORCID 0000-0003-2959-9160
Jong-Seung LeeAmtixBio Co., Ltd., Hanam-si, Gyeonggi-do, South Korea.ORCID 0000-0002-6257-331X
Yong-Sun BahnDepartment of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul, South Korea.ORCID 0000-0001-9573-5752
Yonsei University · KRSungkyunkwan University · KRDuke University · US

Funding

Structure, function, and evolution of the Cryptococcus MAT locusR01AI050113 · NIAID · DUKE UNIVERSITY · PI HEITMAN, JOSEPH · 2002 to 2024
$8.5M
ROLE OF CALCINEURIN IN C. NEOFORMANS MATING AND FRUITINGR01AI039115 · NIAID · DUKE UNIVERSITY · PI HEITMAN, JOSEPH · 1997 to 2025
$6.7M
Genetics of Cryptococcus sexual reproductionR37AI039115 · NIAID · DUKE UNIVERSITY · PI HEITMAN, JOSEPH · 2011 to 2020
$4.9M
NIAID NIH HHS R01 AI039115NIAID NIH HHS R01 AI050113NIAID NIH HHS R37 AI039115
6 · The paper itself

Abstract

The casein kinase 2 (CK2) complex has garnered extensive attention over the past decades as a potential therapeutic target for diverse human diseases, including cancer, diabetes, and obesity, due to its pivotal roles in eukaryotic growth, differentiation, and metabolic homeostasis. While CK2 is also considered a promising antifungal target, its role in fungal pathogens remains unexplored. In this study, we investigated the functions and regulatory mechanisms of the CK2 complex in

Indexed as

CryptococcosisCryptococcus neoformansDiabetes MellitusMeningitis, FungalNeoplasmsAnimalsAntifungal AgentsCalcineurinCalciumCasein Kinase IIHumansMiceObesityProteomicsSignal TransductionAntifungal AgentsCalcineurinCalciumCasein Kinase IICK2Cka1Ckb1Ckb2fungal meningitis

Identifiers

PMID38193728
PMCPMC10865844
OpenAlexW4390706230

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.