Evidence map›Paper›PMID 38193705›Full record

ArticleAntimicrobial agents and chemotherapy2024

Tartrolon E, a secondary metabolite of a marine symbiotic bacterium, is a potent inhibitor of asexual and sexual

Laura Chery-Karschney, Rapatbhorn Patrapuvich, Devaraja Gouda Mudeppa, Sreekanth Kokkonda, Rimi Chakrabarti, Patchara Sriwichai, Roberta M O'Connor, Pradipsinh K Rathod, John White

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Complete genome sequences of two shipworm endosymbiont strains,Microbiology resource announcements · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Laura Chery-KarschneyDepartment of Chemistry, University of Washington, Seattle, Washington, USA.ORCID 0000-0002-2829-902X
Rapatbhorn PatrapuvichDrug Research Unit for Malaria, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Devaraja Gouda MudeppaDepartment of Chemistry, University of Washington, Seattle, Washington, USA.
Sreekanth KokkondaDepartment of Chemistry, University of Washington, Seattle, Washington, USA.
Rimi ChakrabartiDepartment of Chemistry, University of Washington, Seattle, Washington, USA.ORCID 0000-0002-0336-7428
Patchara SriwichaiDepartment of Medical Entomology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Roberta M O'ConnorDepartment of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, Minneapolis, Minnesota, USA.
Pradipsinh K RathodDepartment of Chemistry, University of Washington, Seattle, Washington, USA.
John WhiteDepartment of Chemistry, University of Washington, Seattle, Washington, USA.
University of Washington · USMahidol University · THUniversity of Minnesota · US

Funding

Shared TechnologyU19AI089688 · NIAID · UNIVERSITY OF WASHINGTON · PI RATHOD, PRADIPSINH K. · 2010 to 2023
$22.4M
Investigation of a shipworm endosymbiont compound with activity against the AIDS-associated pathogens Cryptosporidium and ToxoplasmaR21AT009174 · NCCIH · WASHINGTON STATE UNIVERSITY · PI O'CONNOR, ROBERTA M · 2016 to 2017
$468k
NCCIH NIH HHS R21 AT009174NIAID NIH HHS U19 AI089688
6 · The paper itself

Abstract

Due to the spread of resistance to front-line artemisinin derivatives worldwide, there is a need for new antimalarials. Tartrolon E (TrtE), a secondary metabolite of a symbiotic bacterium of marine bivalve mollusks, is a promising antimalarial because it inhibits the growth of sexual and asexual blood stages of

Indexed as

AntimalarialsArtemisininsLactonesMalaria, FalciparumHumansPlasmodium falciparumAntimalarialsArtemisininsLactonestartrolon Egametocidalmalariamarine natural productshipworm symbiont

Identifiers

PMID38193705
PMCPMC10848769
OpenAlexW4390768701

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.