Evidence map›Paper›PMID 38193667›Full record

ArticleAntimicrobial agents and chemotherapy2024

Identification and optimization of pyridine carboxamide-based scaffold as a drug lead for

Padam Singh, Arun Kumar, Pankaj Sharma, Saurabh Chugh, Ashish Kumar, Nidhi Sharma, Sonu Gupta, Manisha Singh, Saqib Kidwai, Jishnu Sankar and 5 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.6field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Pentamidine inhibition of streptopain attenuatesbioRxiv : the preprint server for biology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Padam Singh *Translational Health Sciences and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India.ORCID 0000-0002-8844-9157
Arun Kumar *Translational Health Sciences and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India.
Pankaj SharmaTranslational Health Sciences and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India.
Saurabh ChughTranslational Health Sciences and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India.
Ashish KumarDepartment of Life Science, Laboratory of Mycobacterial Immunology, National Institute of Technology, Rourkela, India.
Nidhi SharmaTranslational Health Sciences and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India.
Sonu GuptaTranslational Health Sciences and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India.
Manisha SinghTranslational Health Sciences and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India.
Saqib KidwaiTranslational Health Sciences and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India.
Jishnu SankarTranslational Health Sciences and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India.
Neha TanejaTranslational Health Sciences and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India.
Yashwant KumarTranslational Health Sciences and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India.
Rohan DhimanDepartment of Life Science, Laboratory of Mycobacterial Immunology, National Institute of Technology, Rourkela, India.
Dinesh MahajanTranslational Health Sciences and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India.ORCID 0000-0002-7939-9506
Ramandeep SinghTranslational Health Sciences and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India.ORCID 0000-0003-2705-3826
Translational Health Science and Technology Institute · INNational Institute of Technology Rourkela · IN

Funding

Department of Biotechnology, Ministry of Science and Technology, India (DBT) BT/PR30159/MED/15/188/2018
6 · The paper itself

Abstract

New drugs with novel mechanisms of action are urgently needed to tackle the issue of drug-resistant tuberculosis. Here, we have performed phenotypic screening using the Pathogen Box library obtained from the Medicines for Malaria Venture against

Indexed as

Mycobacterium bovisMycobacterium tuberculosisTuberculosisAnimalsAntitubercular AgentsIsoniazidMiceAntitubercular AgentsIsoniazid1-aminoisoquinoline5-butyl-2-pyridinecarboxylic acidAmiCautophagyMycobacterium tuberculosispyridine carboxamide

Identifiers

PMID38193667
PMCPMC10848774
OpenAlexW4390735606

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.