Evidence map›Paper›PMID 38193658›Full record

ArticleMicrobiology spectrum2024

Rapid nanopore sequencing and predictive susceptibility testing of positive blood cultures from intensive care patients with sepsis.

Patrick N A Harris, Michelle J Bauer, Lukas Lüftinger, Stephan Beisken, Brian M Forde, Ross Balch, Menino Cotta, Luregn Schlapbach, Sainath Raman, Kiran Shekar and 7 more

Abstract read
In one paragraph

Article in Microbiology spectrum, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed.

  1. Trial
  2. Review
  3. Applicability of Nanopore-only whole-genome sequencing forJournal of clinical microbiology · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Advances in the detection of Drug-Resistant bacteria: current trends and innovations.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026
    Review
  12. Article
  13. Article
  14. Review
  15. Review
  16. Infection and immunity · 2025
    Review
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Patrick N A HarrisUQ Centre for Clinical Research, Faculty of Medicine, University of Queensland, Brisbane, Australia.ORCID 0000-0002-2895-0345
Michelle J BauerUQ Centre for Clinical Research, Faculty of Medicine, University of Queensland, Brisbane, Australia.
Lukas LüftingerAres Genetics GmbH, Carlbergergasse, Vienna, Austria.
Stephan BeiskenAres Genetics GmbH, Carlbergergasse, Vienna, Austria.
Brian M FordeUQ Centre for Clinical Research, Faculty of Medicine, University of Queensland, Brisbane, Australia.ORCID 0000-0002-2264-4785
Ross BalchUQ Centre for Clinical Research, Faculty of Medicine, University of Queensland, Brisbane, Australia.
Menino CottaUQ Centre for Clinical Research, Faculty of Medicine, University of Queensland, Brisbane, Australia.ORCID 0000-0002-2058-2314
Luregn SchlapbachUniversity Children's Hospital Zurich, University of Zurich, Zurich, Switzerland.
Sainath RamanChild Health Research Centre, The University of Queensland, Brisbane, Queensland, Australia.
Kiran ShekarAdult Intensive Care Services, The Prince Charles Hospital, Brisbane, Queensland, Australia.
Peter KrugerIntensive Care Unit, Princess Alexandra Hospital, Woolloongabba, Queensland, Australia.
Jeff LipmanUQ Centre for Clinical Research, Faculty of Medicine, University of Queensland, Brisbane, Australia.
Seweryn BialasiewiczAustralian Centre for Ecogenomics, School of Chemistry and Molecular Biosciences, Faculty of Science, University of Queensland, Brisbane, Australia.ORCID 0000-0001-9474-6943
Lachlan CoinDepartment of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Victoria, Australia.
Jason A RobertsUQ Centre for Clinical Research, Faculty of Medicine, University of Queensland, Brisbane, Australia.ORCID 0000-0001-6218-435X
David L PatersonUQ Centre for Clinical Research, Faculty of Medicine, University of Queensland, Brisbane, Australia.
Adam D IrwinUQ Centre for Clinical Research, Faculty of Medicine, University of Queensland, Brisbane, Australia.

Funding

Brisbane Diamantina Health Partners Health System Improvement Ideas GrantDHAC | National Health and Medical Research Council (NHMRC) Centre of Research Excellence (APP2007007)DHAC | National Health and Medical Research Council (NHMRC) Early Career Research Fellowship (GNT1157530)DHAC | National Health and Medical Research Council (NHMRC) Investigator Grant (GNT1197743)Queensland Government (State of Queensland) Queensland Genomics
6 · The paper itself

Abstract

We aimed to evaluate the performance of Oxford Nanopore Technologies (ONT) sequencing from positive blood culture (BC) broths for bacterial identification and antimicrobial susceptibility prediction. Patients with suspected sepsis in four intensive care units were prospectively enrolled. Human-depleted DNA was extracted from positive BC broths and sequenced using ONT (MinION). Species abundance was estimated using Kraken2, and a cloud-based system (AREScloud) provided

Indexed as

Nanopore SequencingSepsisAnti-Bacterial AgentsBlood CultureCritical CareHumansMicrobial Sensitivity TestsAnti-Bacterial Agentsbloodstream infectionlong-read whole-genome sequencingnanopore

Identifiers

PMID38193658
PMCPMC10846127

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.