Evidence map›Paper›PMID 38193363›Full record

ReviewThe Prostate2024

Link between circadian rhythm and benign prostatic hyperplasia (BPH)/lower urinary tract symptoms (LUTS).

Dana Cavanaugh, Alfonso Urbanucci, Nihal E Mohamed, Ashutosh K Tewari, Mariana Figueiro, Natasha Kyprianou

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The Prostate, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
5.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Benzyl Benzoate Isolation fromPharmaceuticals (Basel, Switzerland) · 2025
    Article
  4. Article
  5. Review
  6. Risk factors for benign prostatic hyperplasia: a comprehensive review.Revista da Associacao Medica Brasileira (1992) · 2025
    Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 3 countries.

Dana CavanaughDepartment of Urology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.ORCID 0000-0002-8636-503X
Alfonso UrbanucciProstate Cancer Research Center, Faculty of Medicine and Health Technology and FiCanMid, Tampere University, Tampere, Finland.
Nihal E MohamedDepartment of Urology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Ashutosh K TewariDepartment of Urology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Mariana FigueiroTisch Cancer Institute at Mount Sinai, New York, New York, USA.
Natasha KyprianouDepartment of Urology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.ORCID 0000-0002-9382-9664
Tisch Hospital · USOslo University Hospital · NO

Funding

Treatment-Induced Phenotypic Reprogramming in Prostate CancerR01CA232574 · NCI · UNIVERSITY OF KENTUCKY · PI KYPRIANOU, NATASHA · 2019 to 2023
$2.2M
Novel Approach to Enhance Ostomy Care in Patients with Bladder and Colorectal CancerR21NR016518 · NINR · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MOHAMED, NIHAL · 2017 to 2018
$475k
NCI NIH HHS R01 CA232574NINR NIH HHS R21 NR016518
6 · The paper itself

Abstract

backgroundBenign prostatic hyperplasia (BPH) is the most common urologic disease in aging males, affecting 50% of men over 50 and up to 80% of men over 80 years old. Its negative impact on health-related quality of life implores further investigation into its risk factors and strategies for effective management. Although the exact molecular mechanisms underlying pathophysiological onset of BPH are poorly defined, the current hypothesized contributors to BPH and lower urinary tract symptoms (LUTS) include aging, inflammation, metabolic syndrome, and hormonal changes. These processes are indirectly influenced by circadian rhythm disruption. In this article, we review the recent evidence on the potential association of light changes/circadian rhythm disruption and the onset of BPH and impact on treatment.

methodsA narrative literature review was conducted using PubMed and Google Scholar to identify supporting evidence. The articles referenced ranged from 1975 to 2023.

resultsA clear relationship between BPH/LUTS and circadian rhythm disruption is yet to be established. However, common mediators influence both diseases, including proinflammatory states, metabolic syndrome, and hormonal regulation that can be asserted to circadian disruption. Some studies have identified a possible relationship between general LUTS and sleep disturbance, but little research has been done on the medical management of these diseases and how circadian rhythm disruption further affects treatment outcomes.

conclusionsThere is evidence to implicate a relationship between BPH/LUTS and circadian rhythm disruptions. However, there is scarce literature on potential specific link in medical management of the disease and treatment outcomes with circadian rhythm disruption. Further study is warranted to provide BPH patients with insights into circadian rhythm directed appropriate interventions.

Indexed as

Lower Urinary Tract SymptomsMetabolic SyndromeProstatic HyperplasiaAged, 80 and overHumansMaleQuality of LifeRisk Factorsbenign prostate growthbenign prostatic hyperplasiacircadian rhythm disruptionlightlower urinary tract symptomsracial disparitiesrisk factorstherapeutic management

Identifiers

PMID38193363
PMCPMC10922447
OpenAlexW4391490448

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.