ArticleMagnetic resonance in medicine2024
Assessment of blood-brain barrier leakage and brain oxygenation in Connexin-32 knockout mice with systemic neuroinflammation using pulse electron paramagnetic resonance imaging techniques.
Article in Magnetic resonance in medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 5 citations in OpenAlex.
- Trityl OXO71 Pharmacokinetics and Distribution in Rhesus Macaques.Magnetic resonance in medicine · 2026Article
- Accelerated EPR imaging using deep learning denoising.Magnetic resonance in medicine · 2025Article
- Composite spin probes with adjustable oxygen sensitivity for pulse electron paramagnetic resonance imaging.Magnetic resonance in medicine · 2025Article
- In Vivo Mouse Abdominal Oxygen Imaging And Assessment of Subcutaneously Implanted Beta Cell Replacement Devices.Molecular imaging and biology · 2025Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
purposeThe determination of blood-brain barrier (BBB) integrity and partial pressure of oxygen (pO
methodsFive Connexin-32 (Cx32)-knockout (KO) mice were injected with lipopolysaccharide to induce neuroinflammation for imaging. Three wild-type mice were also used to optimize the imaging procedure and as control animals. An additional seven Cx32-KO mice were used to establish the BBB leakage of trityl using the colorimetric assay. All pEPRI experiments were performed using a preclinical instrument, JIVA-25 (25 mT/720 MHz), at times t = 0, 4, and 6 h following lipopolysaccharide injection. Two pEPRI imaging techniques were used: (a) single-point imaging for obtaining spatial maps to outline the brain and calculate BBB leakage using the signal amplitude, and (b) inversion-recovery electron spin echo for obtaining pO
resultsA statistically significant change in BBB leakage was found using pEPRI with the progression of inflammation in Cx32 KO animals. However, the change in pO
conclusionsFor the first time, we show the ability of pEPRI to provide pO
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Registered trials
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