Evidence map›Paper›PMID 38193187›Full record

ReviewAmerican journal of physiology. Gastrointestinal and liver physiology2024

Highlights of how single-cell analyses are illuminating differentiation and disease in the gastric corpus.

Mahliyah Adkins-Threats, Yang-Zhe Huang, Jason C Mills

Open access · greenAbstract readReview
In one paragraph

Review in American journal of physiology. Gastrointestinal and liver physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Mahliyah Adkins-ThreatsSection of Gastroenterology, Department of Medicine, Baylor College of Medicine, Houston, Texas, United States.ORCID 0000-0002-6924-2433
Yang-Zhe HuangSection of Gastroenterology, Department of Medicine, Baylor College of Medicine, Houston, Texas, United States.
Jason C MillsSection of Gastroenterology, Department of Medicine, Baylor College of Medicine, Houston, Texas, United States.ORCID 0000-0002-0402-4662
Baylor College of Medicine · US

Funding

Tissue Analysis & Molecular Imaging CoreP30DK056338 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI Hashem B El-Serag · 2001 to 2026
$28.3M
REGULATION OF ATROPHY-INDUCED PROGENITOR CELLS IN THE GASTRIC CORPUSR01DK094989 · NIDDK · WASHINGTON UNIVERSITY · PI Jason C Mills · 2012 to 2026
$6.1M
MECHANISMS OF CHIEF CELL DEDIFFERENTIATIONR01DK105129 · NIDDK · WASHINGTON UNIVERSITY · PI Jason C Mills · 2015 to 2026
$5.4M
Mechanisms Governing Expansion of Embryonic Progenitor Cells (EPCs) inMetaplasiaR01CA239645 · NCI · WASHINGTON UNIVERSITY · PI MILLS, JASON C · 2020 to 2024
$2.1M
The Role of Inflammation in Regulating Gastric MetaplasiaR01DK134531 · NIDDK · SAINT LOUIS UNIVERSITY · PI Richard J DiPaolo · 2023 to 2026
$2.1M
NCI NIH HHS R01 CA239645NIDDK NIH HHS P30 DK056338NIDDK NIH HHS R01 DK094989NIDDK NIH HHS R01 DK105129NIDDK NIH HHS R01 DK134531
6 · The paper itself

Abstract

Single-cell RNA-sequencing (scRNA-seq) has emerged as a powerful technique to identify novel cell markers, developmental trajectories, and transcriptional changes during cell differentiation and disease onset and progression. In this review, we highlight recent scRNA-seq studies of the gastric corpus in both human and murine systems that have provided insight into gastric organogenesis, identified novel markers for the various gastric lineages during development and in adults, and revealed transcriptional changes during regeneration and tumorigenesis. Overall, by elucidating transcriptional states and fluctuations at the cellular level in healthy and disease contexts, scRNA-seq may lead to better, more personalized clinical treatments for disease progression.

Indexed as

Single-Cell AnalysisStomachAdultAnimalsCell DifferentiationGene Expression ProfilingHumansMiceSequence Analysis, RNAstomachtranscriptional analysistumorigenesis

Identifiers

PMID38193187
PMCPMC11211037
OpenAlexW4390779700

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.