Evidence map›Paper›PMID 38193112›Full record

ReviewBioengineering & translational medicine2024

Cancer vaccines in the clinic.

Morgan E Janes, Alexander P Gottlieb, Kyung Soo Park, Zongmin Zhao, Samir Mitragotri

Abstract readReview
In one paragraph

Review in Bioengineering & translational medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Advancements in immunotherapy for oropharyngeal cancer: Current landscape and future prospects.Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia · 2026
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Morgan E JanesJohn A. Paulson School of Engineering & Applied Sciences, Harvard University Cambridge Massachusetts USA.
Alexander P GottliebJohn A. Paulson School of Engineering & Applied Sciences, Harvard University Cambridge Massachusetts USA.
Kyung Soo ParkJohn A. Paulson School of Engineering & Applied Sciences, Harvard University Cambridge Massachusetts USA.
Zongmin ZhaoDepartment of Pharmaceutical Sciences College of Pharmacy, University of Illinois Chicago Chicago Illinois USA.ORCID https://orcid.org/0000-0001-8979-844X
Samir MitragotriJohn A. Paulson School of Engineering & Applied Sciences, Harvard University Cambridge Massachusetts USA.ORCID https://orcid.org/0000-0002-2459-8305

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vaccines are an important tool in the rapidly evolving repertoire of immunotherapies in oncology. Although cancer vaccines have been investigated for over 30 years, very few have achieved meaningful clinical success. However, recent advances in areas such antigen identification, formulation development and manufacturing, combination therapy regimens, and indication and patient selection hold promise to reinvigorate the field. Here, we provide a timely update on the clinical status of cancer vaccines. We identify and critically analyze 360 active trials of cancer vaccines according to delivery vehicle, antigen type, indication, and other metrics, as well as highlight eight globally approved products. Finally, we discuss current limitations and future applications for clinical translation of cancer vaccines.

Indexed as

cancer vaccineclinical trialsdendritic cellimmunotherapymRNAneoantigenvaccine

Identifiers

PMID38193112
PMCPMC10771564

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.