Commentary: PFKFB3 overexpression in monocytes of patients with colon but not rectal cancer programs pro-tumor macrophages and is indicative for higher risk of tumor relapse.

Nikolay Shakhpazyan, Liudmila Mikhaleva, Arcady Bedzhanyan, Nikolay Sadykhov, Konstantin Midiber, Alexander Orekhov

Open access · goldAbstract readComment

In one paragraph

Article in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

0.2field-weighted citation impact, top 29% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

Advances in the understanding of the role and mechanism of action of PFKFB3‑mediated glycolysis in liver fibrosis (Review).International journal of molecular medicine · 2024
Review

4 · The record

Corrections and comments

Comment on
PFKFB3 overexpression in monocytes of patients with colon but not rectal cancer programs pro-tumor macrophages and is indicative for higher risk of tumor relapse.2022

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Nikolay ShakhpazyanAvtsyn Research Institute of Human Morphology, Petrovsky National Research Center of Surgery, Moscow, Russia.

Liudmila MikhalevaAvtsyn Research Institute of Human Morphology, Petrovsky National Research Center of Surgery, Moscow, Russia.

Arcady BedzhanyanDepartment of Abdominal Surgery and Oncology II (Coloproctology and Uro-Gynecology), Petrovsky National Research Center of Surgery, Moscow, Russia.

Nikolay SadykhovAvtsyn Research Institute of Human Morphology, Petrovsky National Research Center of Surgery, Moscow, Russia.

Konstantin MidiberAvtsyn Research Institute of Human Morphology, Petrovsky National Research Center of Surgery, Moscow, Russia.

Alexander OrekhovAvtsyn Research Institute of Human Morphology, Petrovsky National Research Center of Surgery, Moscow, Russia.

Research Institute of Human Morphology · RUInstitute for Atherosclerosis Research · RURussian Scientific Center of Surgery · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Leukemia, Myeloid, AcuteRectal NeoplasmsColonHumansMacrophagesMonocytesNeoplasm Recurrence, LocalPhosphofructokinase-2PFKFB3 protein, humanPhosphofructokinase-2colorectal cancercytokinesinflammationmetabolismmonocytes

Identifiers

PMID38193086

DOI10.3389/fimmu.2023.1290459

PMCPMC10773737

OpenAlexW4390008643

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.