Evidence map›Paper›PMID 38192421›Full record

ReviewFrontiers in endocrinology2023

Chronic low-grade inflammation and ovarian dysfunction in women with polycystic ovarian syndrome, endometriosis, and aging.

Makoto Orisaka, Tetsuya Mizutani, Yumiko Miyazaki, Aya Shirafuji, Chiyo Tamamura, Masayuki Fujita, Hideaki Tsuyoshi, Yoshio Yoshida

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in endocrinology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 126 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
126citing papers in PubMed, 5 pooled it
35.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

126 citing papers in PubMed, 5 syntheses or guidelines pooled it, 130 citations in OpenAlex.

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  14. Ovarian ageing: from biological constraint to emerging therapeutic frontier.Journal of assisted reproduction and genetics · 2026
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66 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Makoto OrisakaDepartment of Obstetrics and Gynecology, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.
Tetsuya MizutaniDepartment of Nursing, Faculty of Nursing and Welfare Sciences, Fukui Prefectural University, Fukui, Japan.
Yumiko MiyazakiDepartment of Obstetrics and Gynecology, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.
Aya ShirafujiDepartment of Obstetrics and Gynecology, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.
Chiyo TamamuraDepartment of Obstetrics and Gynecology, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.
Masayuki FujitaDepartment of Obstetrics and Gynecology, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.
Hideaki TsuyoshiDepartment of Obstetrics and Gynecology, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.
Yoshio YoshidaDepartment of Obstetrics and Gynecology, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.
University of Fukui · JPFukui Prefectural University · JPIshikawa Prefectural Central Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The ovarian microenvironment is critical for follicular development and oocyte maturation. Maternal conditions, including polycystic ovary syndrome (PCOS), endometriosis, and aging, may compromise the ovarian microenvironment, follicular development, and oocyte quality. Chronic low-grade inflammation can induce oxidative stress and tissue fibrosis in the ovary. In PCOS, endometriosis, and aging, pro-inflammatory cytokine levels are often elevated in follicular fluids. In women with obesity and PCOS, hyperandrogenemia and insulin resistance induce ovarian chronic low-grade inflammation, thereby disrupting follicular development by increasing oxidative stress. In endometriosis, ovarian endometrioma-derived iron overload can induce chronic inflammation and oxidative stress, leading to ovarian ferroptosis and fibrosis. In inflammatory aging (inflammaging), senescent cells may secrete senescence-associated secretory phenotype factors, causing chronic inflammation and oxidative stress in the ovary. Therefore, controlling chronic low-grade inflammation and fibrosis in the ovary would present a novel therapeutic strategy for improving the follicular microenvironment and minimizing ovarian dysfunction.

Indexed as

EndometriosisPolycystic Ovary SyndromeAgingFemaleFibrosisHumansInflammationTumor Microenvironmentagingendometriosisfollicular microenvironmentinflammationovarian dysfunctionpolycystic ovarian syndrome

Identifiers

PMID38192421
PMCPMC10773729
OpenAlexW4389684551

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.