ArticleThe Journal of neuropsychiatry and clinical neurosciences2024
Impulsivity and Psychiatric Diagnoses as Mediators of Suicidal Ideation and Suicide Attempts Among Veterans With Traumatic Brain Injury.
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Article in The Journal of neuropsychiatry and clinical neurosciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
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Who cites it
3 citing papers in PubMed, 7 citations in OpenAlex.
- Traumatic Brain Injury and Suicidal Thoughts and Behaviors among Post-9/11 Veterans: Investigating Longitudinal Change and Interactions with Mental Health.Psychiatry research · 2025Article
- Veterans at High Risk for Post-COVID-19 Suicide Attempts or Other Self-Directed Violence.JAMA network open · 2025Article
- Frontal Pole Neuromodulation for Impulsivity and Suicidality in Veterans With Mild Traumatic Brain Injury and Common Co-Occurring Mental Health Conditions: Protocol for a Pilot Randomized Controlled Trial.JMIR research protocols · 2024Article
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Authors and funding
10 authors at 1 institution in 1 country.
Alexandra L AaronsonMental Health Service Line (Aaronson) and Research Service Line (Smith, Bender-Pape, Herrold), Edward J. Hines Veterans Administration Hospital, Hines, Ill.; Department of Psychiatry, University of Illinois, Chicago (Aaronson); Brain Innovation Center, Shirley Ryan AbilityLab, Chicago (Krese); Chicago Association for Research and Education in Science, Hines, Ill. (Krese); Rocky Mountain Mental Illness Research, Education, and Clinical Center for Suicide Prevention, Rocky Mountain Regional Veterans Affairs Medical Center, Aurora, Colo. (Barnhart, Brenner); Department of Physical Medicine and Rehabilitation, University of Colorado Anschutz Medical Campus, Aurora (Barnhart, Brenner); Rehabilitation Service, Veterans Affairs Palo Alto Health Care System, Palo Alto, Calif. (Adamson); Department of Neurosurgery, Stanford University, Stanford, Calif. (Adamson); Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago (de Wit); Center for Neurorestoration and Neurotechnology, Veterans Affairs Providence Health Care System, Providence, R.I. (Philip); Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, R.I. (Philip); Departments of Physical Medicine and Rehabilitation (Bender-Pape) and Psychiatry and Behavioral Sciences (Herrold), Northwestern University, Chicago.
Bridget SmithMental Health Service Line (Aaronson) and Research Service Line (Smith, Bender-Pape, Herrold), Edward J. Hines Veterans Administration Hospital, Hines, Ill.; Department of Psychiatry, University of Illinois, Chicago (Aaronson); Brain Innovation Center, Shirley Ryan AbilityLab, Chicago (Krese); Chicago Association for Research and Education in Science, Hines, Ill. (Krese); Rocky Mountain Mental Illness Research, Education, and Clinical Center for Suicide Prevention, Rocky Mountain Regional Veterans Affairs Medical Center, Aurora, Colo. (Barnhart, Brenner); Department of Physical Medicine and Rehabilitation, University of Colorado Anschutz Medical Campus, Aurora (Barnhart, Brenner); Rehabilitation Service, Veterans Affairs Palo Alto Health Care System, Palo Alto, Calif. (Adamson); Department of Neurosurgery, Stanford University, Stanford, Calif. (Adamson); Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago (de Wit); Center for Neurorestoration and Neurotechnology, Veterans Affairs Providence Health Care System, Providence, R.I. (Philip); Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, R.I. (Philip); Departments of Physical Medicine and Rehabilitation (Bender-Pape) and Psychiatry and Behavioral Sciences (Herrold), Northwestern University, Chicago.
Kelly KreseMental Health Service Line (Aaronson) and Research Service Line (Smith, Bender-Pape, Herrold), Edward J. Hines Veterans Administration Hospital, Hines, Ill.; Department of Psychiatry, University of Illinois, Chicago (Aaronson); Brain Innovation Center, Shirley Ryan AbilityLab, Chicago (Krese); Chicago Association for Research and Education in Science, Hines, Ill. (Krese); Rocky Mountain Mental Illness Research, Education, and Clinical Center for Suicide Prevention, Rocky Mountain Regional Veterans Affairs Medical Center, Aurora, Colo. (Barnhart, Brenner); Department of Physical Medicine and Rehabilitation, University of Colorado Anschutz Medical Campus, Aurora (Barnhart, Brenner); Rehabilitation Service, Veterans Affairs Palo Alto Health Care System, Palo Alto, Calif. (Adamson); Department of Neurosurgery, Stanford University, Stanford, Calif. (Adamson); Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago (de Wit); Center for Neurorestoration and Neurotechnology, Veterans Affairs Providence Health Care System, Providence, R.I. (Philip); Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, R.I. (Philip); Departments of Physical Medicine and Rehabilitation (Bender-Pape) and Psychiatry and Behavioral Sciences (Herrold), Northwestern University, Chicago.
Meghan BarnhartMental Health Service Line (Aaronson) and Research Service Line (Smith, Bender-Pape, Herrold), Edward J. Hines Veterans Administration Hospital, Hines, Ill.; Department of Psychiatry, University of Illinois, Chicago (Aaronson); Brain Innovation Center, Shirley Ryan AbilityLab, Chicago (Krese); Chicago Association for Research and Education in Science, Hines, Ill. (Krese); Rocky Mountain Mental Illness Research, Education, and Clinical Center for Suicide Prevention, Rocky Mountain Regional Veterans Affairs Medical Center, Aurora, Colo. (Barnhart, Brenner); Department of Physical Medicine and Rehabilitation, University of Colorado Anschutz Medical Campus, Aurora (Barnhart, Brenner); Rehabilitation Service, Veterans Affairs Palo Alto Health Care System, Palo Alto, Calif. (Adamson); Department of Neurosurgery, Stanford University, Stanford, Calif. (Adamson); Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago (de Wit); Center for Neurorestoration and Neurotechnology, Veterans Affairs Providence Health Care System, Providence, R.I. (Philip); Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, R.I. (Philip); Departments of Physical Medicine and Rehabilitation (Bender-Pape) and Psychiatry and Behavioral Sciences (Herrold), Northwestern University, Chicago.
Maheen AdamsonMental Health Service Line (Aaronson) and Research Service Line (Smith, Bender-Pape, Herrold), Edward J. Hines Veterans Administration Hospital, Hines, Ill.; Department of Psychiatry, University of Illinois, Chicago (Aaronson); Brain Innovation Center, Shirley Ryan AbilityLab, Chicago (Krese); Chicago Association for Research and Education in Science, Hines, Ill. (Krese); Rocky Mountain Mental Illness Research, Education, and Clinical Center for Suicide Prevention, Rocky Mountain Regional Veterans Affairs Medical Center, Aurora, Colo. (Barnhart, Brenner); Department of Physical Medicine and Rehabilitation, University of Colorado Anschutz Medical Campus, Aurora (Barnhart, Brenner); Rehabilitation Service, Veterans Affairs Palo Alto Health Care System, Palo Alto, Calif. (Adamson); Department of Neurosurgery, Stanford University, Stanford, Calif. (Adamson); Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago (de Wit); Center for Neurorestoration and Neurotechnology, Veterans Affairs Providence Health Care System, Providence, R.I. (Philip); Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, R.I. (Philip); Departments of Physical Medicine and Rehabilitation (Bender-Pape) and Psychiatry and Behavioral Sciences (Herrold), Northwestern University, Chicago.
Harriet de WitMental Health Service Line (Aaronson) and Research Service Line (Smith, Bender-Pape, Herrold), Edward J. Hines Veterans Administration Hospital, Hines, Ill.; Department of Psychiatry, University of Illinois, Chicago (Aaronson); Brain Innovation Center, Shirley Ryan AbilityLab, Chicago (Krese); Chicago Association for Research and Education in Science, Hines, Ill. (Krese); Rocky Mountain Mental Illness Research, Education, and Clinical Center for Suicide Prevention, Rocky Mountain Regional Veterans Affairs Medical Center, Aurora, Colo. (Barnhart, Brenner); Department of Physical Medicine and Rehabilitation, University of Colorado Anschutz Medical Campus, Aurora (Barnhart, Brenner); Rehabilitation Service, Veterans Affairs Palo Alto Health Care System, Palo Alto, Calif. (Adamson); Department of Neurosurgery, Stanford University, Stanford, Calif. (Adamson); Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago (de Wit); Center for Neurorestoration and Neurotechnology, Veterans Affairs Providence Health Care System, Providence, R.I. (Philip); Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, R.I. (Philip); Departments of Physical Medicine and Rehabilitation (Bender-Pape) and Psychiatry and Behavioral Sciences (Herrold), Northwestern University, Chicago.
Noah S PhilipMental Health Service Line (Aaronson) and Research Service Line (Smith, Bender-Pape, Herrold), Edward J. Hines Veterans Administration Hospital, Hines, Ill.; Department of Psychiatry, University of Illinois, Chicago (Aaronson); Brain Innovation Center, Shirley Ryan AbilityLab, Chicago (Krese); Chicago Association for Research and Education in Science, Hines, Ill. (Krese); Rocky Mountain Mental Illness Research, Education, and Clinical Center for Suicide Prevention, Rocky Mountain Regional Veterans Affairs Medical Center, Aurora, Colo. (Barnhart, Brenner); Department of Physical Medicine and Rehabilitation, University of Colorado Anschutz Medical Campus, Aurora (Barnhart, Brenner); Rehabilitation Service, Veterans Affairs Palo Alto Health Care System, Palo Alto, Calif. (Adamson); Department of Neurosurgery, Stanford University, Stanford, Calif. (Adamson); Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago (de Wit); Center for Neurorestoration and Neurotechnology, Veterans Affairs Providence Health Care System, Providence, R.I. (Philip); Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, R.I. (Philip); Departments of Physical Medicine and Rehabilitation (Bender-Pape) and Psychiatry and Behavioral Sciences (Herrold), Northwestern University, Chicago.
Lisa A BrennerMental Health Service Line (Aaronson) and Research Service Line (Smith, Bender-Pape, Herrold), Edward J. Hines Veterans Administration Hospital, Hines, Ill.; Department of Psychiatry, University of Illinois, Chicago (Aaronson); Brain Innovation Center, Shirley Ryan AbilityLab, Chicago (Krese); Chicago Association for Research and Education in Science, Hines, Ill. (Krese); Rocky Mountain Mental Illness Research, Education, and Clinical Center for Suicide Prevention, Rocky Mountain Regional Veterans Affairs Medical Center, Aurora, Colo. (Barnhart, Brenner); Department of Physical Medicine and Rehabilitation, University of Colorado Anschutz Medical Campus, Aurora (Barnhart, Brenner); Rehabilitation Service, Veterans Affairs Palo Alto Health Care System, Palo Alto, Calif. (Adamson); Department of Neurosurgery, Stanford University, Stanford, Calif. (Adamson); Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago (de Wit); Center for Neurorestoration and Neurotechnology, Veterans Affairs Providence Health Care System, Providence, R.I. (Philip); Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, R.I. (Philip); Departments of Physical Medicine and Rehabilitation (Bender-Pape) and Psychiatry and Behavioral Sciences (Herrold), Northwestern University, Chicago.
Theresa Bender-PapeMental Health Service Line (Aaronson) and Research Service Line (Smith, Bender-Pape, Herrold), Edward J. Hines Veterans Administration Hospital, Hines, Ill.; Department of Psychiatry, University of Illinois, Chicago (Aaronson); Brain Innovation Center, Shirley Ryan AbilityLab, Chicago (Krese); Chicago Association for Research and Education in Science, Hines, Ill. (Krese); Rocky Mountain Mental Illness Research, Education, and Clinical Center for Suicide Prevention, Rocky Mountain Regional Veterans Affairs Medical Center, Aurora, Colo. (Barnhart, Brenner); Department of Physical Medicine and Rehabilitation, University of Colorado Anschutz Medical Campus, Aurora (Barnhart, Brenner); Rehabilitation Service, Veterans Affairs Palo Alto Health Care System, Palo Alto, Calif. (Adamson); Department of Neurosurgery, Stanford University, Stanford, Calif. (Adamson); Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago (de Wit); Center for Neurorestoration and Neurotechnology, Veterans Affairs Providence Health Care System, Providence, R.I. (Philip); Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, R.I. (Philip); Departments of Physical Medicine and Rehabilitation (Bender-Pape) and Psychiatry and Behavioral Sciences (Herrold), Northwestern University, Chicago.
Amy A HerroldMental Health Service Line (Aaronson) and Research Service Line (Smith, Bender-Pape, Herrold), Edward J. Hines Veterans Administration Hospital, Hines, Ill.; Department of Psychiatry, University of Illinois, Chicago (Aaronson); Brain Innovation Center, Shirley Ryan AbilityLab, Chicago (Krese); Chicago Association for Research and Education in Science, Hines, Ill. (Krese); Rocky Mountain Mental Illness Research, Education, and Clinical Center for Suicide Prevention, Rocky Mountain Regional Veterans Affairs Medical Center, Aurora, Colo. (Barnhart, Brenner); Department of Physical Medicine and Rehabilitation, University of Colorado Anschutz Medical Campus, Aurora (Barnhart, Brenner); Rehabilitation Service, Veterans Affairs Palo Alto Health Care System, Palo Alto, Calif. (Adamson); Department of Neurosurgery, Stanford University, Stanford, Calif. (Adamson); Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago (de Wit); Center for Neurorestoration and Neurotechnology, Veterans Affairs Providence Health Care System, Providence, R.I. (Philip); Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, R.I. (Philip); Departments of Physical Medicine and Rehabilitation (Bender-Pape) and Psychiatry and Behavioral Sciences (Herrold), Northwestern University, Chicago.
Edward Hines, Jr. VA Hospital · US
Funding
Neural Target Identification for Functional Disability Associated with Alcohol Related Characteristics Among Veterans with Co-occurring Alcohol Use Disorder and Traumatic Brain InjuryI01RX002916 · VA · EDWARD HINES JR VA HOSPITAL · PI HERROLD, AMY · 2019 to 2025
–VA RR&D Center for Neurorestoration and NeurotechnologyI50RX002864 · VA · PROVIDENCE VA MEDICAL CENTER · PI BENJAMIN D GREENBERG, LEIGH R HOCHBERG · 2018 to 2026
–Establishing Relationships and Developing a Therapeutic Target for Impulsivity and Suicidality Among Veterans with Traumatic Brain Injury and Co-occurring ConditionsIK1RX003082 · VA · EDWARD HINES JR VA HOSPITAL · PI AARONSON, ALEXANDRA LEIGH · 2020 to 2022
–Neuromodulation for impulsivity and suicidality in Veterans with mildtraumatic brain injury and common co-occurring mental health conditionsIK2RX004298 · VA · EDWARD HINES JR VA HOSPITAL · PI Alexandra Leigh Aaronson · 2023 to 2026
–RRD VA I01 RX002916RRD VA I50 RX002864RRD VA IK1 RX003082RRD VA IK2 RX004298
Abstract
objectiveTraumatic brain injury (TBI) is a risk factor for suicide, but questions related to mechanisms remain unanswered. Impulsivity is a risk factor for suicide and is a common sequela of TBI. The authors explored the relationships between TBI and both suicidal ideation and suicide attempts and explored whether impulsivity and comorbid psychiatric diagnoses mediate these relationships.
methodsThis cross-sectional retrospective chart review study included 164 veterans enrolled in a previous study. Sixty-nine veterans had no TBI history, and 95 had a TBI history (mild, N=44; moderate, N=13; severe, N=12; and unclear severity, N=26). To examine the associations between TBI and suicidal ideation or suicide attempts, as well as potential mediators of these relationships, chi-square tests, t tests, and logistic regression models were used.
resultsUnadjusted analyses indicated that veterans with TBI were more likely to report suicidal ideation; however, in analyses controlling for mediators, this relationship was no longer significant. Among veterans with TBI, suicidal ideation was related most strongly to high impulsivity (odds ratio=15.35, 95% CI=2.43-96.79), followed by depression (odds ratio=5.73, 95% CI=2.53-12.99) and posttraumatic stress disorder (odds ratio=2.57, 95% CI=1.03-6.42). TBI was not related to suicide attempts, yet suicide attempts were related to high impulsivity (odds ratio=6.95, 95% CI=1.24-38.75) and depression (odds ratio=3.89, 95% CI=1.56-9.40).
conclusionsThese findings suggest that impulsivity, followed by psychiatric diagnoses, most strongly mediate the relationships between TBI and both suicidal ideation and suicide attempts. Impulsivity may be mechanistically related to, and serve as a future treatment target for, suicidality among veterans with TBI.
Indexed as
Brain Injuries, TraumaticVeteransCross-Sectional StudiesHumansImpulsive BehaviorRetrospective StudiesRisk FactorsSuicidal IdeationSuicide, AttemptedImpulsivityMajor Depressive DisorderSuicidal IdeationSuicide AttemptTraumatic Brain InjuryVeterans
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