ArticleeLife2024
Experience shapes chandelier cell function and structure in the visual cortex.
Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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Who cites it
10 citing papers in PubMed.
- Learning reorganizes dendritic and stabilizes axon initial segment inhibitory synapses in CA1 pyramidal neurons.Nature communications · 2026Article
- Prefrontal chandelier cells encode stimulus salience to influence learning in male mice.Nature communications · 2026Article
- The Highly Localized Interaction between Neurofascin-186 and Gliomedin Promotes Subcellular Innervation by the Chandelier Cell.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- The Role of GABA Pathway Components in Pathogenesis of Neurodevelopmental Disorders.International journal of molecular sciences · 2025Review
- Interactions between homeostatic plasticity and statistical learning: A role for inhibition.Current opinion in neurobiology · 2025Review
- Integrating multimodal data to understand cortical circuit architecture and function.Nature neuroscience · 2025Review
- Theory of axo-axonic inhibition.PLoS computational biology · 2025Article
- Axon initial segment structure and function in health and disease.Physiological reviews · 2025Review
- Modulatory feedback determines attentional object segmentation in a model of the ventral stream.PloS one · 2025Article
- Axo-axonic synaptic input drives homeostatic plasticity by tuning the axon initial segment structurally and functionally.Science advances · 2024Article
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
Detailed characterization of interneuron types in primary visual cortex (V1) has greatly contributed to understanding visual perception, yet the role of chandelier cells (ChCs) in visual processing remains poorly characterized. Using viral tracing we found that V1 ChCs predominantly receive monosynaptic input from local layer 5 pyramidal cells and higher-order cortical regions. Two-photon calcium imaging and convolutional neural network modeling revealed that ChCs are visually responsive but weakly selective for stimulus content. In mice running in a virtual tunnel, ChCs respond strongly to events known to elicit arousal, including locomotion and visuomotor mismatch. Repeated exposure of the mice to the virtual tunnel was accompanied by reduced visual responses of ChCs and structural plasticity of ChC boutons and axon initial segment length. Finally, ChCs only weakly inhibited pyramidal cells. These findings suggest that ChCs provide an arousal-related signal to layer 2/3 pyramidal cells that may modulate their activity and/or gate plasticity of their axon initial segments during behaviorally relevant events.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.