Evidence map›Paper›PMID 38191877›Full record

ArticleBulletin of experimental biology and medicine2023

Recombinant Pneumolysin of Pneumococci Induces TLR4 Expression and Maturation of Dendritic Cells In Vitro.

N K Akhmatova, D S Vorobyev, E S Petukhova, I B Semenova, I V Yakovleva, N F Gavrilova, A E Zaitsev, E A Akhmatova, Yu V Volokh, A Yu Leonova and 2 more

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Article in Bulletin of experimental biology and medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

N K AkhmatovaI. I. Mechnikov Research Institute of Vaccines and Sera, Moscow, Russia.
D S VorobyevI. I. Mechnikov Research Institute of Vaccines and Sera, Moscow, Russia.
E S PetukhovaI. I. Mechnikov Research Institute of Vaccines and Sera, Moscow, Russia.
I B SemenovaI. I. Mechnikov Research Institute of Vaccines and Sera, Moscow, Russia.
I V YakovlevaI. I. Mechnikov Research Institute of Vaccines and Sera, Moscow, Russia.
N F GavrilovaI. I. Mechnikov Research Institute of Vaccines and Sera, Moscow, Russia.
A E ZaitsevI. I. Mechnikov Research Institute of Vaccines and Sera, Moscow, Russia.
E A AkhmatovaI. I. Mechnikov Research Institute of Vaccines and Sera, Moscow, Russia.
Yu V VolokhI. I. Mechnikov Research Institute of Vaccines and Sera, Moscow, Russia.
A Yu LeonovaI. I. Mechnikov Research Institute of Vaccines and Sera, Moscow, Russia.
A V PoddubikovI. I. Mechnikov Research Institute of Vaccines and Sera, Moscow, Russia.
E A KurbatovaI. I. Mechnikov Research Institute of Vaccines and Sera, Moscow, Russia. kurbatova6162@yandex.ru.
Research Institute of Vaccines and Sera. Mechnikov of the Russian Academy of Medical Sciences · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pneumolysin (Ply) is a target for the development of serotype-independent pneumococcal vaccines, an important condition for the efficacy of which is their ability to activate innate immunity with the subsequent formation of adaptive immunity. In this study, the ability of recombinant full-length Ply (rPly) of pneumococci to induce TLR expression and maturation of dendritic cells generated from mouse bone marrow was evaluated. It was shown that rPly in vitro increased the number of dendritic cells expressing Toll-like receptor 4 (TLR4) on the membrane. rPly caused maturation of dendritic cells generated from mouse bone marrow, which manifested in a decrease in the number of progenitor cells (CD34), an increase in the number of cells expressing the adhesion molecule CD38, costimulatory molecules CD80 and CD86, molecules of terminal differentiation of dendritic cells CD83, as well as molecules of antigenic presentation of the major histocompatibility complex class II.

Indexed as

Streptococcus pneumoniaeStreptolysinsToll-Like Receptor 4AnimalsBacterial ProteinsDendritic CellsMiceBacterial ProteinsplY protein, Streptococcus pneumoniaeStreptolysinsToll-Like Receptor 4dendritic cellsrecombinant pneumolysinStreptococcus pneumoniaesurface moleculesToll-like receptors

Identifiers

PMID38191877
OpenAlexW4390660457

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.