Evidence map›Paper›PMID 38191823›Full record

Trial reportPediatric research2024

An exploratory study of clinical factors associated with IGF-1 and IGFBP-3 in preterm infants.

Megan E Paulsen, Nicholas Marka, Emily M Nagel, Juan David Gonzalez Villamizar, Brandon M Nathan, Sara E Ramel

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Pediatric research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Megan E PaulsenDivision of Neonatology, Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN, USA. megan.paulsen@childrensmn.org.
Nicholas MarkaBiostatistical Design and Analysis Center, Clinical Translational Science Institute, University of Minnesota, Minneapolis, MN, USA.
Emily M NagelUniversity of Minnesota School of Public Health, Minneapolis, MN, USA.
Juan David Gonzalez VillamizarDivision of Neonatology, Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN, USA.
Brandon M NathanDivision of Endocrinology, Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN, USA.
Sara E RamelDivision of Neonatology, Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN, USA.
University of Minnesota · USUniversity of Minnesota Medical Center · US

Funding

Univ of Minnesota Buidling Interdisciplinary Research Careers in Women's HealthK12HD055887 · NICHD · UNIVERSITY OF MINNESOTA · PI ALLEN, SHARON S, BERGE, JERICA M · 2007 to 2023
$8.6M
Minnesota Obesity Prevention Training (MnOPT)T32DK083250 · NIDDK · UNIVERSITY OF MINNESOTA · PI KOTZ, CATHERINE M, LASKA, MELISSA N. · 2010 to 2024
$5.1M
Maternal Stress, Human Milk Composition, and Neurodevelopmental and Feeding OutcomesK99HD108276 · NICHD · UNIVERSITY OF MINNESOTA · PI NAGEL, EMILY M · 2022 to 2023
$245k
NICHD NIH HHS K12 HD055887NICHD NIH HHS K99 HD108276NIDDK NIH HHS T32 DK083250
6 · The paper itself

Abstract

backgroundDespite advances in parenteral nutrition, postnatal growth failure in very low birthweight (VLBW) preterm infants is common and associated with chronic health problems. Insulin-like growth factor 1 (IGF-1) is positively associated with improved infant growth, but factors which promote IGF-1 levels in this population have not been clearly identified. The objective of this study was to explore early factors that influence IGF-1 in VLBW preterm infants.

methodsVLBW infants were enrolled into a prospective, randomized controlled nutrition trial (N = 87). Outcome measures included IGF-1 and IGFBP-3 levels measured at 35 weeks PMA. Linear regression analyses tested the relationships between candidate clinical predictors and levels of IGF-1 and IGFBP-3.

resultsHigher protein intake, longer duration of parenteral nutrition, and lower IGFBP-3 levels at 1 week of life were associated with lower IGF-1 levels at 35 weeks PMA. Neither early markers of insulin resistance nor degree of illness were associated with IGF-1 levels at 35 weeks PMA.

conclusionOptimization of early nutrient intake, and attention to route of delivery, may have a lasting influence on IGF-1/IGFBP-3, and in turn, long-term health outcomes. IMPACT: In very low birthweight preterm infants, early protein intake, duration of parenteral nutrition, and insulin-like growth factor binding protein 3 (IGFBP-3) levels at 1 week of life are positively associated with insulin-like growth factor 1 (IGF-1) levels at 35 weeks postmenstrual age. Data from this study highlight the influence of early nutrition on components of the endocrine axis in preterm infants. Strategies aimed at early initiation of enteral nutrition, as well as optimizing composition of parenteral nutrition, may bolster hormones involved in promoting preterm infant growth.

Indexed as

Infant, PrematureInfant, Very Low Birth WeightInsulin-Like Growth Factor Binding Protein 3Insulin-Like Growth Factor IParenteral NutritionBiomarkersFemaleGestational AgeHumansInfant, NewbornInfant Nutritional Physiological PhenomenaMaleProspective StudiesBiomarkersIGF1 protein, humanIGFBP3 protein, humanInsulin-Like Growth Factor Binding Protein 3Insulin-Like Growth Factor I

Identifiers

PMID38191823
PMCPMC11228126
OpenAlexW4390671691

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.