Evidence map›Paper›PMID 38191817›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2024

A bis-boron boramino acid PET tracer for brain tumor diagnosis.

Zhu Li, Junyi Chen, Ziren Kong, Yixin Shi, Mengxin Xu, Bo-Shuai Mu, Nan Li, Wenbin Ma, Zhi Yang, Yu Wang and 1 more

Erratum issuedAbstract read
PubMed Publisher
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
4.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Detailed pharmacokinetic features of a novel bis-boronEuropean journal of nuclear medicine and molecular imaging · 2026
    Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. CD98 Light Chain LAT1 Tracers in PET-CT Diagnosis of Cancer Patients.Anti-cancer agents in medicinal chemistry · 2026
    Review
  7. Review
  8. Article
  9. A histogram of [EJNMMI research · 2024
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 3 countries.

Zhu Li *Key Laboratory of Carcinogenesis and Translational Research, Department of Nuclear Medicine, Peking University Cancer Hospital & Institute, Beijing, China.
Junyi Chen *Beijing National Laboratory for Molecular Sciences, Radiochemistry and Radiation Chemistry Key Laboratory of Fundamental Science, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, NMPA Key Laboratory for Research and Evaluation of Radiopharmaceuticals, Peking University, Beijing, China.
Ziren KongDepartment of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Yixin ShiDepartment of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Mengxin XuBeijing National Laboratory for Molecular Sciences, Radiochemistry and Radiation Chemistry Key Laboratory of Fundamental Science, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, NMPA Key Laboratory for Research and Evaluation of Radiopharmaceuticals, Peking University, Beijing, China.
Bo-Shuai MuBeijing National Laboratory for Molecular Sciences, Radiochemistry and Radiation Chemistry Key Laboratory of Fundamental Science, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, NMPA Key Laboratory for Research and Evaluation of Radiopharmaceuticals, Peking University, Beijing, China.
Nan LiKey Laboratory of Carcinogenesis and Translational Research, Department of Nuclear Medicine, Peking University Cancer Hospital & Institute, Beijing, China.
Wenbin MaDepartment of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Zhi YangKey Laboratory of Carcinogenesis and Translational Research, Department of Nuclear Medicine, Peking University Cancer Hospital & Institute, Beijing, China.
Yu WangDepartment of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. ywang@pumch.cn.
Zhibo LiuKey Laboratory of Carcinogenesis and Translational Research, Department of Nuclear Medicine, Peking University Cancer Hospital & Institute, Beijing, China. zbliu@pku.edu.cn.ORCID 0000-0002-5587-4165
Peking University · CNChinese Academy of Medical Sciences & Peking Union Medical College · CN

Funding

Changping Laboratory Changping LaboratoryMinistry of Science and Technology of the People's Republic of China 2021YFA1601400National High Level Hospital Clinical Research Funding 2022-PUMCH-A-019National Natural Science Foundation of China 22225603Natural Science Foundation of Beijing Municipality 7232351Natural Science Foundation of Beijing Municipality Z200018Science Foundation of Peking University Cancer Hospital PY202309Special Research Fund for Central Universities, and Peking Union Medical College 3332022024
6 · The paper itself

Abstract

purposeBoramino acids are a class of amino acid biomimics that replace the carboxylate group with trifluoroborate and can achieve the

methodsThis study reports a trifluoroborate-derived boronophenylalanine (BBPA), a derived boronophenylalanine (BPA) for BNCT, as a promising PET tracer for tumor imaging.

resultsCompetition inhibition assays in cancer cells suggested the cell accumulation of [

conclusionThis study outlines a clinical trial with [

Indexed as

Boron CompoundsBrain NeoplasmsFluorine RadioisotopesPhenylalaninePositron Emission Tomography Computed TomographyRadioactive TracersAnimalsBoron Neutron Capture TherapyBrainFemaleHealthy VolunteersHumansLarge Neutral Amino Acid-Transporter 1Magnetic Resonance ImagingMelanoma, ExperimentalMice4-boronophenylalanineBoron CompoundsFluorine RadioisotopesLarge Neutral Amino Acid-Transporter 1Molecular ProbesPhenylalanineRadioactive TracersBoramino acidBrain tumorPositron emission tomography

Identifiers

PMID38191817
OpenAlexW4390730991

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.