Evidence map›Paper›PMID 38191801›Full record

ArticleTransplant infectious disease : an official journal of the Transplantation Society2024

COVID-19 in organ donors: An organ procurement organization perspective.

Alyssa K Mezochow, Judith Anesi, Sharon West, Richard Hasz, John Edwards, Emily A Blumberg

Open access · bronzeAbstract read
In one paragraph

Article in Transplant infectious disease : an official journal of the Transplantation Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Alyssa K MezochowPerelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID https://orcid.org/0000-0002-0838-2627
Judith AnesiPerelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Sharon WestGift of Life Donor Program, Philadelphia, Pennsylvania, USA.
Richard HaszGift of Life Donor Program, Philadelphia, Pennsylvania, USA.
John EdwardsGift of Life Donor Program, Philadelphia, Pennsylvania, USA.
Emily A BlumbergPerelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID https://orcid.org/0000-0002-5193-6170
Gift of Life Michigan · USUniversity of Pennsylvania · US

Funding

Infectious Diseases Epidemiology Training GrantT32AI055435 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI LAUTENBACH, EBBING · 2003 to 2023
$6.9M
NIAID NIH HHS T32 AI055435
6 · The paper itself

Abstract

backgroundThe COVID-19 pandemic presented a significant challenge for Organ Procurement Organizations (OPOs) with the use of SARS-CoV-2 positive donors varying widely. This study used detailed single OPO data to determine the success of using SARS-CoV-2 positive donors.

methodsWe performed a retrospective cohort study including all SARS-CoV-2 positive donors referred to the Gift of Life OPO from January 1, 2021, to June 30, 2023. Descriptive analyses were performed to characterize referral and organ utilization.

resultsThere were 861 organ referrals with 1 positive SARS-Cov-2 test: 282 were ruled out with telephone evaluation, 431 referrals were ruled out with onsite evaluation ("evaluated nondonors") and 148 became donors. For donors who had both nasopharyngeal and lower respiratory testing completed, there was notable result discordance observed. Median cycle threshold (Ct) values were similar between donors and evaluated nondonors with no change in median donor Ct values over the study period. Transplanted organs from COVID-positive donors included 27 hearts, 88 livers, 5 pancreata, and 107 kidneys; no lung donation occurred. The proportion of COVID-positive donors significantly increased over the study period.

conclusionThis large volume donor referral study demonstrates increasing COVID-19 referrals progressing to donation over time, supporting the increased use of these donors for nonlung transplantation.

Indexed as

COVID-19Organ TransplantationTissue and Organ ProcurementHumansPandemicsRetrospective StudiesSARS-CoV-2Tissue DonorsCOVID‐19organ donorsorgan procurement organization

Identifiers

PMID38191801
PMCPMC11156261
OpenAlexW4390777840

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.