ArticleEnvironmental science and pollution research international2024
In-vivo and in-silico studies to identify toxicity mechanisms of permethrin with the toxicity-reducing role of ginger.
Article in Environmental science and pollution research international, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21 citing papers in PubMed, 28 citations in OpenAlex.
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- Application of Allium cepa Test for Genetic Toxicology.Methods in molecular biology (Clifton, N.J.) · 2026Article
- The mitigating effects of Tribulus terrestris extract on the cytotoxic, genotoxic, biochemical and phytotoxic effects of omethoate in roots of Allium cepa bulbs.Scientific reports · 2025Article
- Chemical profiling by LC-MS/MS and GC-MS and biological activity assessment of different extracts of Portulaca oleracea through in-vitro and in-silico approaches.Scientific reports · 2025Article
- Eco-friendly remediation of Triflumuron-induced stress with Capsella bursa-pastoris extract.Scientific reports · 2025Article
- Integrated evaluation of methidathion-induced toxicity in Allium cepa with a multifactorial biological approach.Scientific reports · 2025Article
- Quantitative phenolic profiling and protective effects of grape seed extract on mancozeb-induced cellular and genetic toxicity.Scientific reports · 2025Article
- Multifaceted investigation of toxicity induced by overdoses of trace element iron with the Allium cepa.Scientific reports · 2025Article
- Toxicological insights into the non-target effects of ornidazole using the Allium cepa bioassay system.Scientific reports · 2025Article
- The natural and eco-friendly role of Cassia angustifolia in reducing carbaryl toxicity at environmentally relevant concentration.Scientific reports · 2025Article
- In-silico receptor interactions, phytochemical fingerprint and biological activities of Matricaria chamomilla flower extract and the main components.Scientific reports · 2025Article
- A study investigating the multifaceted toxicity induced by triflumuron insecticide in Allium cepa L.Scientific reports · 2025Article
- Investigation of in-vivo and in-silico toxicity induced by environmental drug contamination in a non-target organism.Scientific reports · 2025Article
- Synergistic and antagonistic contributions of main components to the bioactivity profile of Anethum graveolens extract.Scientific reports · 2025Article
- Toxicological assessment of omethoate insecticide in Allium cepa L.Scientific reports · 2025Article
- Multifaceted investigation of esfenvalerate-induced toxicity on Allium cepa L.Scientific reports · 2025Article
- An Assessment of the Cyto-Genotoxicity Effects of Green-Synthesized Silver Nanoparticles and ATCBRA Insecticide on the Root System ofNanomaterials (Basel, Switzerland) · 2025Article
- Alleviatory efficacy of achillea millefolium L. in etoxazole-mediated toxicity in allium cepa L.Scientific reports · 2024Article
- Investigation of multidirectional toxicity induced by high-dose molybdenum exposure with Allium test.Scientific reports · 2024Article
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4 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
In this study, the toxic effects of permethrin on Allium cepa L. and the protective role of Zingiber officinale rhizome extract (Zoex) were investigated. In this context, 6 different groups were formed. While the control group was treated with tap water, the groups II and III were treated with 10 µg/mL and 20 µg/mL Zoex, respectively, and the group IV was treated with 100 µg/L permethrin. The protective effect of Zoex against permethrin toxicity was studied as a function of dose, and groups V and VI formed for this purpose were treated with 10 µg/mL Zoex + 100 µg/L permethrin and 20 µg/mL Zoex + 100 µg/L permethrin, respectively. After 72 h of germination, cytogenetic, biochemical, physiological, and anatomical changes in meristematic cells of A. cepa were studied. As a result, permethrin application decreased the mitotic index (MI) and increased the frequency of micronuclei (MN), and chromosomal abnormalities. The increase in malondialdehyde (MDA), superoxide dismutase (SOD), and catalase (CAT) and the decrease in glutathione (GSH) indicate that permethrin causes oxidative damage. Compared to the control group, a 68.5% decrease in root elongation (p < 0.05) and an 81.8% decrease (p < 0.05) in weight gain were observed in the permethrin-treated group. It was found that the application of Zoex together with permethrin resulted in regression of all detected abnormalities, reduction in the incidence of anatomical damage, MN and chromosomal aberrations, and improvement in MI rates. The most significant improvement was observed in group VI treated with 20 µg/mL Zoex, and Zoex was also found to provide dose-dependent protection. The toxicity mechanism of permethrin was also elucidated by molecular docking and spectral studies. From the data obtained during the study, it was found that permethrin has toxic effects on A. cepa, a non-target organism, while Zoex plays a protective role by reducing these effects.
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