ArticleNature metabolism2024
Depletion of JunB increases adipocyte thermogenic capacity and ameliorates diet-induced insulin resistance.
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Article in Nature metabolism, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
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Who cites it
14 citing papers in PubMed, 12 citations in OpenAlex.
- Nuclear Translocation of PFKFB3 Promotes Disuse-Induced Muscle Atrophy via Scaffolding Nedd4-Mediated JunB Ubiquitination.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Understanding adipocyte heterogeneity across species, depot, and disease.Biochemical Society transactions · 2026Review
- N6-(2-Hydroxyethyl) Adenosine Alleviates Hepatic Steatosis and Insulin Resistance by Inhibiting JunB+ Adipocytes.Phytotherapy research : PTR · 2026Article
- Novel perspectives on PPARγ regulation: from SPPARMs to the emerging role of lncRNAs in metabolic disorders.International journal of obesity (2005) · 2026Review
- Integrative ATAC-Seq and RNA-Seq analysis identifies key genes for intramuscular fat content in Laiwu pigs.BMC genomics · 2026Article
- Article
- Inhibition of adipocyte RUNX1/2 enhances adipose tissue thermogenesis through distinct mechanisms.Nature communications · 2026Article
- Fos-induced osteosarcoma growth causes a cachexia-like phenotype in mice and correlates with high Fgf21 serum levels.Cancer & metabolism · 2026Article
- Periodic fasting and refeeding re-shapes lipid saturation, storage, and distribution in brown adipose tissue.PLoS biology · 2026Article
- Adipose Inositol Monophosphate Metabolism Is Associated with Fasting Regimen-Elicited Metabolic Benefits.Biomolecules · 2025Article
- TRIM56 Promotes White Adipose Tissue Browning to Attenuate Obesity by Degrading TLE3.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Dissecting genomes of multiple yak populations: unveiling ancestry and high-altitude adaptation through whole-genome resequencing analysis.BMC genomics · 2025Article
- Exploring the biological functions and immune regulatory roles of IRAK3, TNFRSF1A, CX3CR1, and JUNB in T2DM combined with MAFLD: integrated bioinformatics and single-cell analysis.Frontiers in immunology · 2025Article
- Depletion of JunB increases adipocyte thermogenic capacity and ameliorates diet-induced insulin resistance.Metabolism open · 2024Article
Corrections and comments
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Authors and funding
22 authors at 3 institutions in 2 countries.
Xing ZhangDepartment of Biochemistry and Molecular Biology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.ORCID http://orcid.org/0000-0002-5877-627X
Xiaofeng DingDepartment of Biochemistry and Molecular Biology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
Chunqing WangDepartment of Biochemistry and Molecular Biology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.ORCID http://orcid.org/0000-0002-2811-7230
Que LeDepartment of Biochemistry and Molecular Biology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
Dandan WuDepartment of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.ORCID http://orcid.org/0000-0003-2073-5998
Anying SongDepartment of Molecular & Cellular Endocrinology, City of Hope Comprehensive Cancer Center, Duarte, CA, USA.
Guixiang HuangThe National and Local Joint Engineering Laboratory of Animal Peptide Drug Development, College of Life Sciences, Hunan Normal University, Changsha, People's Republic of China.
Liping LuoDepartment of Biochemistry and Molecular Biology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.ORCID http://orcid.org/0000-0002-5649-1289
Yan LuoDepartment of Biochemistry and Molecular Biology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.ORCID http://orcid.org/0000-0001-9642-0576
Xin YangDepartment of Biochemistry and Molecular Biology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
Aleyah E GoinsDepartment of Biochemistry and Molecular Biology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.ORCID http://orcid.org/0000-0002-1834-9994
Sharina P DesaiAutophagy Inflammation and Metabolism Center for Biomedical Research Excellence, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
Chengrui QiuDepartment of Biochemistry and Molecular Biology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
Floyd D SilvaDepartment of Biochemistry and Molecular Biology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.ORCID http://orcid.org/0000-0001-8328-2469
Lily Elizabeth FeldmanDepartment of Biochemistry and Molecular Biology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.ORCID http://orcid.org/0000-0001-5561-7786
Jianlin ZhouThe National and Local Joint Engineering Laboratory of Animal Peptide Drug Development, College of Life Sciences, Hunan Normal University, Changsha, People's Republic of China.ORCID http://orcid.org/0000-0001-8640-5364
Michael F SpaffordDepartment of Surgery, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
Nathan H BoydDepartment of Surgery, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
Eric R ProssnitzAutophagy Inflammation and Metabolism Center for Biomedical Research Excellence, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.ORCID http://orcid.org/0000-0001-9190-8302
Xuexian O YangDepartment of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.ORCID http://orcid.org/0000-0001-6816-7024
Qiong A WangDepartment of Molecular & Cellular Endocrinology, City of Hope Comprehensive Cancer Center, Duarte, CA, USA.ORCID http://orcid.org/0000-0003-2224-4287
Meilian LiuDepartment of Biochemistry and Molecular Biology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA. meilianliu@salud.unm.edu.ORCID http://orcid.org/0000-0003-1639-262X
University of New Mexico · USCity of Hope · USHunan Normal University · CN
Funding
WOMEN'S CANCERS RESEARCH PROGRAMP30CA118100 · NCI · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Yolanda Sanchez · 2005 to 2026
$57.1MUNM HSC Clinical and Translational Science CenterUL1TR001449 · NCATS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI CAMPEN, MATTHEW J, PANDHI, NANCY · 2015 to 2024
$36.9MUnfolded Protein Response and Autophagy in T Helper Cell Effector FunctionP20GM121176 · NIGMS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Monica Rosas Lemus · 2017 to 2026
$24.9MIntegrative Program in CNS Pathophysiology ResearchP30GM103400 · NIGMS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI LIU, KE JIAN · 2012 to 2016
$4.7MMolecular Mechanisms and Applications of Novel ER/GPER-selective LigandsR01CA194496 · NCI · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI ARTERBURN, JEFFREY B, PROSSNITZ, ERIC R · 2016 to 2025
$4.1MG protein-coupled estrogen receptor GPER and breast carcinogenesisR01CA163890 · NCI · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI PROSSNITZ, ERIC R · 2012 to 2023
$3.3MThe Role of Adiponectin in Regulating Group 2 Innate Lymphoid Cells and Browning in FatR01DK110439 · NIDDK · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI LIU, MEILIAN · 2017 to 2021
$1.8MThe Cytokine Suppressor CIS in Giant Cell PneumonitisR01HL148337 · NHLBI · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI YANG, XUEXIAN · 2020 to 2023
$1.5MTranscriptional Control of High-thermogenic Adipocyte DevelopmentR01DK132643 · NIDDK · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI LIU, MEILIAN · 2022 to 2025
$1.5MNCATS NIH HHS UL1 TR001449NCI NIH HHS P30 CA118100NCI NIH HHS R01 CA163890NCI NIH HHS R01 CA194496NHLBI NIH HHS R01 HL148337NIDDK NIH HHS R01 DK110439NIDDK NIH HHS R01 DK132643NIGMS NIH HHS P20 GM121176NIGMS NIH HHS P30 GM103400
Abstract
The coexistence of brown adipocytes with low and high thermogenic activity is a fundamental feature of brown adipose tissue heterogeneity and plasticity. However, the mechanisms that govern thermogenic adipocyte heterogeneity and its significance in obesity and metabolic disease remain poorly understood. Here we show that in male mice, a population of transcription factor jun-B (JunB)-enriched (JunB
Indexed as
Insulin ResistanceAdipocytes, BrownAnimalsDiet, High-FatMaleMiceObesityPPAR gammaTranscription FactorsJunB protein, mousePPAR gammaTranscription Factors
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.