ArticleNature communications2024
Functional neuronal circuits emerge in the absence of developmental activity.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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Who cites it
13 citing papers in PubMed, 30 citations in OpenAlex.
- Topographically organized dorsal raphe activity modulates forebrain sensory-motor representations and contributes to defensive behaviors.Nature communications · 2026Article
- Visualizing the multidimensional landscape of biological variation in modern microscopy.Frontiers in bioinformatics · 2026Article
- Preconfigured neuronal firing sequences in human brain organoids.Nature neuroscience · 2026Article
- Linking brain and behavior states in Zebrafish Larvae locomotion using hidden Markov models.PLoS computational biology · 2026Article
- Remote control of wildtype zebrafish optomotor response with a photoswitchable drug.Frontiers in behavioral neuroscience · 2026Article
- Panx1a modulates metabolic stress signaling and synaptic composition in the developing zebrafish brain.Cell and tissue research · 2025Article
- Three systems of circuit formation: assembly, updating and tuning.Nature reviews. Neuroscience · 2025Review
- Emergence of input selective recurrent dynamics via information transfer maximization.Scientific reports · 2024Article
- Isochronic development of cortical synapses in primates and mice.Nature communications · 2023Article
- Against cortical reorganisation.eLife · 2023Article
- Neuroscience Needs Network Science.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Neuroscience needs Network Science.ArXiv · 2023Article
- Complex computation from developmental priors.Nature communications · 2023Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The complex neuronal circuitry of the brain develops from limited information contained in the genome. After the genetic code instructs the birth of neurons, the emergence of brain regions, and the formation of axon tracts, it is believed that temporally structured spiking activity shapes circuits for behavior. Here, we challenge the learning-dominated assumption that spiking activity is required for circuit formation by quantifying its contribution to the development of visually-guided swimming in the larval zebrafish. We found that visual experience had no effect on the emergence of the optomotor response (OMR) in dark-reared zebrafish. We then raised animals while pharmacologically silencing action potentials with the sodium channel blocker tricaine. After washout of the anesthetic, fish could swim and performed with 75-90% accuracy in the OMR paradigm. Brain-wide imaging confirmed that neuronal circuits came 'online' fully tuned, without requiring activity-dependent plasticity. Thus, complex sensory-guided behaviors can emerge through activity-independent developmental mechanisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.