ArticleTranslational psychiatry2024
Optogenetic recruitment of hypothalamic corticotrophin-releasing-hormone (CRH) neurons reduces motivational drive.
Article in Translational psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 11 citations in OpenAlex.
- Behavioral and Biochemical Effects of Vitexin-Isovitexin-Loaded Microcapsule Combination on Restraint Stress Mouse Model.International journal of molecular sciences · 2026Article
- Vagal control of the brain-esophagus axis ameliorates stress-induced esophageal motility dysfunction in male mice.Molecular metabolism · 2026Article
- Selective and differential roles of PVHNature communications · 2026Article
- Neuro-Immune Crosstalk: Molecular Mechanisms, Biological Functions, Diseases, and Therapeutic Targets.MedComm · 2026Review
- Sleep deprivation engages the orexin/hypocretin system to regulate food reward seeking.The international journal of neuropsychopharmacology · 2025Article
- Role of Hypothalamic CRH Neurons in Regulating the Impact of Stress on Memory and Sleep.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- The paraventricular nucleus of the hypothalamus: a key node in the control of behavioural states.The Journal of physiology · 2025Review
- Application of Optogenetic Neuromodulation in Regulating Depression.Current medical science · 2025Review
- The Hypothalamic Medial Preoptic Area-Paraventricular Nucleus Circuit Modulates Depressive-Like Behaviors in a Mouse Model of Postpartum Depression.Research (Washington, D.C.) · 2025Article
- Contribution of hypothalamic orexin (hypocretin) circuits to pathologies of motivation.British journal of pharmacology · 2024Review
- A hypothalamic circuit mechanism underlying the impact of stress on memory and sleep.bioRxiv : the preprint server for biology · 2024Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
Abstract
Impaired motivational drive is a key feature of depression. Chronic stress is a known antecedent to the development of depression in humans and depressive-like states in animals. Whilst there is a clear relationship between stress and motivational drive, the mechanisms underpinning this association remain unclear. One hypothesis is that the endocrine system, via corticotropin-releasing hormone (CRH) in the paraventricular nucleus of the hypothalamus (PVN; PVN
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.