Evidence map›Paper›PMID 38191326›Full record

Observational studyBMC infectious diseases2024

Efficacy of single antibiotic therapy versus antibiotic combination in implant-free staphylococcal post-surgical spinal infections: a retrospective observational study.

Amélie Lombès, Marie-Paule Fernandez-Gerlinger, Marc Khalifé, Najiby Kassis-Chikhani, Amira Jomli, Jean-Luc Mainardi, David Lebeaux, Marie Dubert

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMC infectious diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 100% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Amélie LombèsMobile infectious disease unit, Service de Microbiologie, AP-HP, Hôpital Européen Georges Pompidou, APHP-Centre, 20 rue Leblanc, 75015, Paris, France. amelie.lombes@gmail.com.
Marie-Paule Fernandez-GerlingerMobile infectious disease unit, Service de Microbiologie, AP-HP, Hôpital Européen Georges Pompidou, APHP-Centre, 20 rue Leblanc, 75015, Paris, France.
Marc KhaliféOrthopedic surgery unit, AP-HP, Hôpital Européen Georges Pompidou, APHP-Centre, 20 rue Leblanc, 75015, Paris, France.
Najiby Kassis-ChikhaniInfection control unit, AP-HP, Hôpital Européen Georges Pompidou, APHP-Centre, 20 rue Leblanc, 75015, Paris, France.
Amira JomliMicrobiology laboratory, AP-HP, Hôpital Européen Georges Pompidou, APHP- Centre, 20 rue Leblanc, 75015, Paris, France.
Jean-Luc MainardiMobile infectious disease unit, Service de Microbiologie, AP-HP, Hôpital Européen Georges Pompidou, APHP-Centre, 20 rue Leblanc, 75015, Paris, France.
David LebeauxMobile infectious disease unit, Service de Microbiologie, AP-HP, Hôpital Européen Georges Pompidou, APHP-Centre, 20 rue Leblanc, 75015, Paris, France.
Marie DubertMobile infectious disease unit, Service de Microbiologie, AP-HP, Hôpital Européen Georges Pompidou, APHP-Centre, 20 rue Leblanc, 75015, Paris, France.
Assistance Publique – Hôpitaux de Paris · FRHôpital Européen · FRHôpital Européen Georges-Pompidou · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPost-surgical spinal infections (pSSIs) are a serious complication of spinal surgeries, with Staphylococcus spp. being one of the most prominent bacteria identified. Optimal antimicrobial therapy for staphylococcal spinal infections without spinal implants is not well documented.

methodsThis single center retrospective 7-year observational study described and compared the outcome (treatment failure or mortality rate one year after diagnosis) of 20 patients with staphylococcal-implant-free pSSI treated with single or combination antibiotics.

resultsMedian duration of treatment was 40 days (IQR 38-42), with 6 days (IQR 5-7) on intravenous antibiotics and 34 days (IQR 30-36) on oral therapy. Four patients (20%) underwent new surgical debridement, all due to surgical failure, and 1 patient died within the first year without significant differences between both treatment group.

conclusionThis study raises the possibility of single antibiotic therapy for patients with implant-free post-surgical spinal infections due to Staphylococcus spp.

Indexed as

Postoperative ComplicationsStaphylococcal InfectionsAnti-Bacterial AgentsHumansRetrospective StudiesStaphylococcusAnti-Bacterial AgentsCombination antibioticImplant-freeSingle antibioticSpinalStaphylococcusSurgical site infections (SSIs)

Identifiers

PMID38191326
PMCPMC10775553
OpenAlexW4390662344

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.