Evidence map›Paper›PMID 38190702›Full record

ArticleAmerican journal of respiratory and critical care medicine2024

Serum Cell-Free DNA-based Detection of

Lin Li, Emily Henkle, Brady M Youngquist, Seungyeon Seo, Kamal Hamed, David Melnick, Christopher J Lyon, Li Jiang, Adrian M Zelazny, Tony Y Hu and 2 more

Erratum issued Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of respiratory and critical care medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT07301320 (A Randomized, Double-Blind, Placebo-Controlled, Multicenter, Prospective, Investigator-Initiated Trial to Assess the Efficacy, Safety, and Pharmacokinetics of Epetraborole in Patients With Mycobacterium Abscessus Lung Disease), which is not on this map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07301320 phase2recruitingnot on this mapstarted 2026, after this paper: background citation

A Randomized, Double-Blind, Placebo-Controlled, Multicenter, Prospective, Investigator-Initiated Trial to Assess the Efficacy, Safety, and Pharmacokinetics of Epetraborole in Patients With Mycobacterium Abscessus Lung Disease: REBOUND Study

TypeinterventionalSponsorKevin WinthropRan2026 to 2028Enrolled84ConditionsMycobacterium Abscessus InfectionArmsEpetraborole, Placebo
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. [Microbiological Characteristics of Extrapulmonary Nontuberculous Mycobacterial Infections in a Tertiary Hospital].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2026
    Article
  3. Article
  4. IJTLD open · 2026
    Article
  5. Review
  6. Review
  7. Review
  8. Erratum: Serum Cell-Free DNA-based Detection ofAmerican journal of respiratory and critical care medicine · 2024
    Article
  9. Is It Time to Say Goodbye to Sputum?American journal of respiratory and critical care medicine · 2024
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Lin LiDepartment of Laboratory Medicine and Sichuan Provincial Key Laboratory for Human Disease Gene Study, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, China.
Emily HenkleOHSU-PSU School of Public Health and.
Brady M YoungquistCenter for Cellular and Molecular Diagnostics, Department of Biochemistry and Molecular Biology, School of Medicine, and.
Seungyeon SeoDepartment of Laboratory Medicine, NIH Clinical Center, NIH, Bethesda, MD; and.
Kamal HamedSpero Therapeutics, Cambridge, MA.ORCID 0000-0003-1896-9736
David MelnickSpero Therapeutics, Cambridge, MA.
Christopher J LyonCenter for Cellular and Molecular Diagnostics, Department of Biochemistry and Molecular Biology, School of Medicine, and.
Li JiangDepartment of Laboratory Medicine and Sichuan Provincial Key Laboratory for Human Disease Gene Study, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, China.
Adrian M ZelaznyDepartment of Laboratory Medicine, NIH Clinical Center, NIH, Bethesda, MD; and.
Tony Y HuCenter for Cellular and Molecular Diagnostics, Department of Biochemistry and Molecular Biology, School of Medicine, and.ORCID 0000-0001-7255-5409
Kevin L WinthropDivision of Infectious Diseases, Schools of Medicine and Public Health, Oregon Health & Science University, Portland, OR.
Bo NingCenter for Cellular and Molecular Diagnostics, Department of Biochemistry and Molecular Biology, School of Medicine, and.
National Institutes of Health Clinical Center · USSichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital · CNSpero Therapeutics (United States) · USOregon Health & Science University · USTulane University · US

Funding

Oregon Clinical and Translational Research Institute - The National COVID Cohort Collaborative (N3C)UL1TR002369 · NCATS · OREGON HEALTH & SCIENCE UNIVERSITY · PI Cynthia D Morris, Christopher G. Slatore · 2017 to 2026
$78.4M
Tulane University COVID Antibody and Immunity Network (TUCAIN) SupplementU54CA260581 · NCI · TULANE UNIVERSITY OF LOUISIANA · PI ROBINSON, JAMES E · 2020 to 2024
$9.2M
Direct quantitation of the circulating Mtb-peptidome for pediatric TB managementR01HD090927 · NICHD · TULANE UNIVERSITY OF LOUISIANA · PI Christopher J Lyon, Charles DeBeaux Mitchell · 2017 to 2026
$4.5M
Mtb and HIV/SIV antigen peptide signatures as blood biomarkers to detect early infection to active disease in young children and NHPR01HD103511 · NICHD · TULANE UNIVERSITY OF LOUISIANA · PI LYON, CHRISTOPHER J · 2021 to 2025
$3.7M
Digital Nanoplasmonic Quantification of Tumor-derived Extracellular Vesicles in Plasma MicrosamplesU01CA252965 · NCI · TULANE UNIVERSITY OF LOUISIANA · PI HU, TONY Y., LU, HUA · 2020 to 2024
$3.0M
A nanopore biosensor for leveling Mtb antigens in bloodR01AI144168 · NIAID · TULANE UNIVERSITY OF LOUISIANA · PI Christopher J Lyon · 2022 to 2026
$3.0M
Quantification of brain-derived extracellular vesicle microRNAs in blood by a liposome-mediated CRISPR assay for traumatic brain injury detectionR21NS130542 · NINDS · TULANE UNIVERSITY OF LOUISIANA · PI HU, TONY Y. · 2022 to 2022
$437k
Liposome fusion enabled extracellular vesicle detection for COVID-19R21AI169582 · NIAID · TULANE UNIVERSITY OF LOUISIANA · PI NING, BO · 2022 to 2023
$419k
Identification of Clinically Important Microbes by Genomic and Proteomic MethodsZIACL080012 · CLC · CLINICAL CENTER · PI ZELAZNY, ADRIAN MARCELO · 2009 to 2025
$0k
Eunice Kennedy Shriver National Institute of Child Health and Human Development R01HD090927National Institute of Allergy and Infectious Diseases R01AI144168NCATS NIH HHS UL1 TR002369NCATS NIH HHS UL1TR002369NCI NIH HHS U01 CA252965NCI NIH HHS U01CA252965NCI NIH HHS U54 CA260581NIAID NIH HHS R01 AI144168NIAID NIH HHS R21 AI169582NICHD NIH HHS R01 HD090927NICHD NIH HHS R01 HD103511NINDS NIH HHS R21 NS130542NINDS NIH HHS R21NS130542U.S. Department of Defense W81XWH1910026
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Cell-Free Nucleic AcidsMycobacterium avium ComplexMycobacterium avium-intracellulare InfectionAgedAnti-Bacterial AgentsClustered Regularly Interspaced Short Palindromic RepeatsCohort StudiesDNA, BacterialFemaleHumansMaleMiddle AgedSensitivity and SpecificityAnti-Bacterial AgentsCell-Free Nucleic AcidsDNA, Bacterialclustered regularly interspaced short palindromic repeatsmolecular diagnosticsMycobacterium avium complexpulmonary disease

Identifiers

PMID38190702
PMCPMC11146540
OpenAlexW4390658872

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.