Evidence map›Paper›PMID 38190628›Full record

Trial reportBlood advances2024

Limited efficacy for ibrutinib and venetoclax in T-prolymphocytic leukemia: results from a phase 2 international study.

Marco Herling, Claire Dearden, Francesco Zaja, Dima El-Sharkawi, Wei Ding, Mar Bellido, Amit Khot, Lidwine Tick, Eric Jacobsen, Toby A Eyre and 10 more

Open access · goldAbstract readClinical Trial, Phase II
In one paragraph

Trial report in Blood advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 13 institutions in 7 countries.

Marco HerlingDepartment of Internal Medicine I, University Hospital Cologne, Cologne, Germany.
Claire DeardenThe Royal Marsden NHS Foundation Trust, London, United Kingdom.
Francesco ZajaUCO Ematologia, Azienda Sanitaria Universitaria Giuliano Isontina, Trieste, Italy.ORCID 0000-0003-3995-8817
Dima El-SharkawiThe Royal Marsden NHS Foundation Trust, London, United Kingdom.ORCID 0000-0002-2752-5814
Wei DingDivision of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN.
Mar BellidoDepartment of Hematology, University Medical Center Groningen, Groningen, The Netherlands.ORCID 0000-0001-9864-5816
Amit KhotDepartment of Clinical Haematology, Peter MacCallum Cancer Center, The Royal Melbourne Hospital and The University of Melbourne, Melbourne, Australia.ORCID 0000-0002-9210-5373
Lidwine TickDepartment of Internal Medicine, Máxima Medical Center, Eindhoven, The Netherlands.
Eric JacobsenDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA.
Toby A EyreOxford Cancer & Haematology Centre, Churchill Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom.ORCID 0000-0002-6631-9749
Damien Roos-WeilSorbonne Université, Assistance Publique-Hôpitaux de Paris, Service Hematologie Clinique, Hopital Pitie Salpetriere, Paris, France.ORCID 0000-0002-7767-755X
Tapan KadiaDepartment of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX.
Elisa LucchiniUCO Ematologia, Azienda Sanitaria Universitaria Giuliano Isontina, Trieste, Italy.ORCID 0000-0002-4857-8325
Natali PflugDepartment of Internal Medicine I, University Hospital Cologne, Cologne, Germany.ORCID 0000-0002-3895-7065
Matthew S DavidsDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA.
German PenaDepartment of Global Medical Affairs, Oncology, AbbVie, North Chicago, IL.
Nabanita MukherjeeDepartment of GSMD-Statistics, AbbVie, North Chicago, IL.
Mohamed BadawiDepartment of CPPM Clinical PK/PD, AbbVie, North Chicago, IL.
Tamas VizkeletyDepartment of Global Medical Affairs, Oncology, AbbVie, North Chicago, IL.
Philipp B StaberUniversitaetsklinik fuer Innere Medizin I, Klinische Abteilung fuer Haematologie und Haemostaseologie, Medizinische Universitaet Wien, Vienna, Austria.ORCID 0000-0001-6729-7708
AbbVie (United States) · USUniversity Hospital Cologne · DEDana-Farber Cancer Institute · USRoyal Marsden NHS Foundation Trust · GBAzienda Sanitaria Universitaria Integrata di Trieste · ITChurchill Hospital · GBMayo Clinic · USRadboud University Nijmegen · NLSorbonne Université · FRThe Royal Melbourne Hospital · AUThe University of Texas MD Anderson Cancer Center · USUniversity Medical Center Groningen · NLUniversity of Trieste · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Leukemia, Prolymphocytic, T-CellPiperidinesSulfonamidesAdenineBridged Bicyclo Compounds, HeterocyclicHumansAdenineBridged Bicyclo Compounds, HeterocyclicibrutinibPiperidinesSulfonamidesvenetoclax

Identifiers

PMID38190628
PMCPMC10874748
OpenAlexW4390660983

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.