ArticleProceedings of the National Academy of Sciences of the United States of America2024
MFP1 defines the subchloroplast location of starch granule initiation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Loss of the plastidial hexokinase CsHXK3 triggers metabolic starvation and ROS imbalance leading to pollen abortion in cucumber.The Plant journal : for cell and molecular biology · 2026Article
- Article
- LIKE EARLY STARVATION is involved in the regulation of starch initiation in potato tubers (Solanum tuberosum cv. Désirée).Journal of experimental botany · 2026Article
- Chloroplast heat shock protein cpHsc70-1 interacts with thylakoid membrane remodeling protein VIPP1 C-terminal tail and controls VIPP1 oligomer assembly.PNAS nexus · 2026Article
- Protein targeting to Starch 2 and the plastidial phosphorylase 1 revealed protein-protein interactions with photosynthesis proteins in yeast two-hybrid screenings.Plant signaling & behavior · 2025Article
- Article
- Old player, new roles: defining the role of the plastidial phosphorylase.The New phytologist · 2025Review
- A point mutation in the photosystem II protein PsbW disrupts thylakoid organization and alters starch granule formation.Plant physiology · 2025Article
- Branched oligosaccharides cause atypical starch granule initiation in Arabidopsis chloroplasts.Plant physiology · 2025Article
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Authors and funding
8 authors.
Funding
Abstract
Starch is one of the major carbohydrate storage compounds in plants. The biogenesis of starch granules starts with the formation of initials, which subsequently expand into granules. Several coiled-coil domain-containing proteins have been previously implicated with the initiation process, but the mechanisms by which they act remain largely elusive. Here, we demonstrate that one of these proteins, the thylakoid-associated MAR-BINDING FILAMENT-LIKE PROTEIN 1 (MFP1), specifically determines the subchloroplast location of initial formation. The expression of MFP1 variants "mis"-targeted to specific locations within chloroplasts in Arabidopsis results in distinctive shifts in not only how many but also where starch granules are formed. Importantly, "re" localizing MFP1 to the stromal face of the chloroplast's inner envelope is sufficient to generate starch granules in this aberrant position. These findings provide compelling evidence that a single protein MFP1 possesses the capacity to direct the initiation and biosynthesis machinery of starch granules.
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