Evidence map›Paper›PMID 38190534›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

Efr3b is essential for social recognition by modulating the excitability of CA2 pyramidal neurons.

Xiaojie Wei, Jing Wang, Enlu Yang, Yiping Zhang, Qi Qian, Xuekun Li, Fude Huang, Binggui Sun

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Xiaojie Wei *Department of Anesthesiology of the Children's Hospital and School of Brain Science and Brain Medicine, Zhejiang University School of Medicine and National Clinical Research Center for Child Health, Zhejiang University, Hangzhou 310058, China.ORCID 0009-0002-7630-9760
Jing Wang *Department of Anesthesiology of the Children's Hospital and School of Brain Science and Brain Medicine, Zhejiang University School of Medicine and National Clinical Research Center for Child Health, Zhejiang University, Hangzhou 310058, China.
Enlu YangDepartment of Anesthesiology of the Children's Hospital and School of Brain Science and Brain Medicine, Zhejiang University School of Medicine and National Clinical Research Center for Child Health, Zhejiang University, Hangzhou 310058, China.
Yiping ZhangDepartment of Anesthesiology of the Children's Hospital and School of Brain Science and Brain Medicine, Zhejiang University School of Medicine and National Clinical Research Center for Child Health, Zhejiang University, Hangzhou 310058, China.
Qi QianDepartment of Anesthesiology of the Children's Hospital and School of Brain Science and Brain Medicine, Zhejiang University School of Medicine and National Clinical Research Center for Child Health, Zhejiang University, Hangzhou 310058, China.
Xuekun LiChildren's Hospital and Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou 310020, China.ORCID 0000-0002-6985-6363
Fude HuangSino-Danish College, University of Chinese Academy of Sciences, Beijing 100190, China.
Binggui SunDepartment of Anesthesiology of the Children's Hospital and School of Brain Science and Brain Medicine, Zhejiang University School of Medicine and National Clinical Research Center for Child Health, Zhejiang University, Hangzhou 310058, China.ORCID 0000-0002-0386-6569
Chinese Academy of Medical Sciences & Peking Union Medical College · CNChildren's Hospital of Zhejiang University · CNShaoxing University · CNUniversity of Chinese Academy of Sciences · CN

Funding

MOST | National Key Research and Development Program of China Stem Cell and Translational Research (Stem Cell and Translational Research) 2019YFA0110103MOST | National Key Research and Development Program of China Stem Cell and Translational Research (Stem Cell and Translational Research) 2021YFA1101701MOST | National Natural Science Foundation of China (NSFC) 31871025MOST | National Natural Science Foundation of China (NSFC) 32071031MOST | National Natural Science Foundation of China (NSFC) 32271028
6 · The paper itself

Abstract

CA2 pyramidal neurons (PNs) are associated with social behaviors. The mechanisms, however, remain to be fully investigated. Here, we report that Efr3b, a protein essential for phospholipid metabolism at the plasma membrane, is widely expressed in the brain, especially in the hippocampal CA2/CA3 areas. To assess the functional significance of Efr3b in the brain, we generated Efr3b

Indexed as

BrainRecognition, PsychologyAnimalsCell MembraneMiceMice, Inbred C57BLPyramidal CellsCA2Efr3bexcitabilitypyramidal neuronsocial novelty

Identifiers

PMID38190534
PMCPMC10801834
OpenAlexW4390660286

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.