ArticleJournal of the American Chemical Society2024
Electrochemical Vicinal C-H Difunctionalization of Saturated Azaheterocycles.
Article in Journal of the American Chemical Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 25 citations in OpenAlex.
- Green electrochemistry-enabled one-pot synthesis of halogenated amides from readily available carboxylic acids.RSC advances · 2026Article
- One-Pot Amidation/C─H Halogenation by an Efficient Electrochemical Cascade.Angewandte Chemie (International ed. in English) · 2026Article
- Electrochemical hydroxylation of alkenes with HNational science review · 2026Article
- Electrochemically deuterated silane synthesis with DScience advances · 2026Article
- Nickelaelectro-Catalyzed C─H Activation to β-Arylated Pyrroles via Multiple Dehydrogenation.Angewandte Chemie (International ed. in English) · 2025Article
- Regiodivergent α- and β-Functionalization of SaturatedJournal of the American Chemical Society · 2025Article
- α,β-Desaturation and Formal β-C(spJournal of the American Chemical Society · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
A method to functionalize two vicinal C-H bonds of saturated azaheterocycles is described. The procedure involves subjecting the substrate to a mixture of hydrochloric acid, acetic acid, and acetic anhydride in an undivided electrochemical cell at a constant current, resulting in stereoselective conversion to the corresponding α-acetoxy-β-chloro derivative. The α-position can be readily substituted with a range of other groups, including alkyl, aryl, allyl, alkynyl, alkoxy, or azido functionalities. Furthermore, we demonstrate that the β-chloro position can be engaged in Suzuki cross-coupling. This protocol thus enables the rapid diversification of simple five-, six-, and seven-membered saturated azaheterocycles at two adjacent positions.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.