ArticleJournal of X-ray science and technology2024
Application of dose-gradient function in reducing radiation induced lung injury in breast cancer radiotherapy.
Article in Journal of X-ray science and technology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed, 1 citations in OpenAlex.
- Construction and evaluation of a predictive model for radiation-induced lung injury in lung cancer: a meta-analysis.American journal of translational research · 2025Review
- Dose-Gradient Function-Guided Reduction of Radiation-Induced Heart Injury in Left-Sided Breast Cancer Treated With Helical Tomotherapy After Mastectomy.Technology in cancer research & treatmentArticle
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTry to create a dose gradient function (DGF) and test its effectiveness in reducing radiation induced lung injury in breast cancer radiotherapy. MATERIALS AND
methodsRadiotherapy plans of 30 patients after breast-conserving surgery were included in the study. The dose gradient function was defined as DGH=VDVp3, then the area under the DGF curve of each plan was calculated in rectangular coordinate system, and the minimum area was used as the trigger factor, and other plans were triggered to optimize for area reduction. The dosimetric parameters of target area and organs at risk in 30 cases before and after re-optimization were compared.
resultsOn the premise of ensuring that the target dose met the clinical requirements, the trigger factor obtained based on DGF could further reduce the V5, V10, V20, V30 and mean lung dose (MLD) of the ipsilateral lung in breast cancer radiotherapy, P < 0.01. And the D2cc and mean heart dose (MHD) of the heart were also reduced, P < 0.01. Besides, the NTCPs of the ipsilateral lung and the heart were also reduced, P < 0.01.
conclusionThe trigger factor obtained based on DGF is efficient in reducing radiation induced lung injury in breast cancer radiotherapy.
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