Evidence map›Paper›PMID 38189712›Full record

ArticleJournal of Parkinson's disease2024

Chronotropic Incompetence During Exercise Testing as a Marker of Autonomic Dysfunction in Individuals with Early Parkinson's Disease.

Garett Griffith, Guillaume Lamotte, Niyati Mehta, Peng Fan, Juliana Nikolich, Victoria Springman, Erin Suttman, Elizabeth Joslin, Katherine Balfany, MacKenzie Dunlap and 7 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Parkinson's disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 13 citations in OpenAlex.

  1. Trial
  2. Trial
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  4. Physical Activity and Exercise for People with Parkinson's Disease: The Past, Present, and Future.Movement disorders : official journal of the Movement Disorder Society · 2026
    Review
  5. Article
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  11. Frontiers in sports and active living · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 6 institutions in 1 country.

Garett GriffithDepartment of Physical Therapy and Human Movement Sciences, Northwestern University, Chicago, IL, USA.
Guillaume LamotteDepartment of Neurology, University of Utah, Salt Lake City, UT, USA.
Niyati MehtaDepartment of Physical Therapy and Human Movement Sciences, Northwestern University, Chicago, IL, USA.
Peng FanDepartment of Physical Therapy and Human Movement Sciences, Northwestern University, Chicago, IL, USA.
Juliana NikolichDepartment of Physical Therapy and Human Movement Sciences, Northwestern University, Chicago, IL, USA.
Victoria SpringmanDepartment of Physical Therapy and Human Movement Sciences, Northwestern University, Chicago, IL, USA.
Erin SuttmanDepartment of Neurology, University of Utah, Salt Lake City, UT, USA.
Elizabeth JoslinDepartment of Physical Therapy and Human Movement Sciences, Northwestern University, Chicago, IL, USA.
Katherine BalfanySchool of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
MacKenzie DunlapCleveland Clinic, Cleveland, OH, USA.
Wendy M KohrtSchool of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Cory L ChristiansenSchool of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Edward L MelansonSchool of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Deborah JosbenoDepartment of Physical Therapy, University of Pittsburgh, Pittsburgh, PA, USA.
Lana M ChahineDepartment of Neurology, University of Pittsburgh, Pittsburgh, PA, USA.
Charity G PattersonDepartment of Physical Therapy, University of Pittsburgh, Pittsburgh, PA, USA.
Daniel M CorcosDepartment of Physical Therapy and Human Movement Sciences, Northwestern University, Chicago, IL, USA.
Northwestern University · USGeriatric Research Education and Clinical Center · USUniversity of Pittsburgh · USUniversity of Utah · USCleveland Clinic · USUniversity of Colorado Anschutz Medical Campus · US

Funding

PILOT STUDY--SUBSTRATE METABOLISM IN EXTREMELY LOW BIRTH WEIGHT INFANTSP30DK048520 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI JANINE A HIGGINS · 1995 to 2026
$32.6M
Study in Parkinson Disease of Exercise Phase 3 Clinical Trial: SPARX3U01NS113851 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Daniel M. Corcos · 2019 to 2026
$29.6M
Exploratory study of different doses of endurance exercise in people with ParkinsR01NS074343 · NINDS · UNIVERSITY OF COLORADO DENVER · PI CORCOS, DANIEL M., SCHENKMAN, MARGARET L · 2011 to 2014
$3.0M
NINDS NIH HHS R01 NS074343NINDS NIH HHS U01 NS113851
6 · The paper itself

Abstract

backgroundAn attenuated heart rate response to exercise, termed chronotropic incompetence, has been reported in Parkinson's disease (PD). Chronotropic incompetence may be a marker of autonomic dysfunction and a cause of exercise intolerance in early stages of PD.

objectiveTo investigate the relationship between chronotropic incompetence, orthostatic blood pressure change (supine - standing), and exercise performance (maximal oxygen consumption, VO2peak) in individuals with early PD within 5 years of diagnosis not on dopaminergic medications.

methodsWe performed secondary analyses of heart rate and blood pressure data from the Study in Parkinson's Disease of Exercise (SPARX).

results128 individuals were enrolled into SPARX (63.7±9.3 years; 57.0% male, 0.4 years since diagnosis [median]). 103 individuals were not taking chronotropic medications, of which 90 had a normal maximal heart rate response to exercise testing (155.3±14.0 bpm; PDnon-chrono) and 13 showed evidence of chronotropic incompetence (121.3±11.3 bpm; PDchrono, p < 0.05). PDchrono had decreased VO2peak compared to PDnon-chrono (19.7±4.5 mL/kg/min and 24.3±5.8 mL/kg/min, respectively, p = 0.027). There was a positive correlation between peak heart rate during exercise and the change in systolic blood pressure from supine to standing (r = 0.365, p < 0.001).

conclusionsA subgroup of individuals with early PD not on dopaminergic medication had chronotropic incompetence and decreased VO2peak, which may be related to autonomic dysfunction. Evaluation of both heart rate responses to incremental exercise and orthostatic vital signs may serve as biomarkers of early autonomic impairment and guide treatment. Further studies should investigate whether cardiovascular autonomic dysfunction affects the ability to exercise and whether exercise training improves autonomic dysfunction.

Indexed as

Autonomic Nervous System DiseasesHeart FailureParkinson DiseaseExercise TestFemaleHeart RateHumansMaleautonomic nervous systemchronotropic incompetenceExerciseheart rateParkinson’s disease

Identifiers

PMID38189712
PMCPMC10836543
OpenAlexW4390619452

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.