Evidence map›Paper›PMID 38189525›Full record

ArticleLab on a chip2024

Quantifying neutrophil extracellular trap release in a combined infection-inflammation NET-array device.

Udaya Sree Datla, Bhaskar Vundurthy, Jessica S Hook, Nidhi Menon, Hossein Razmi Bagtash, Tarik Shihabeddin, David W Schmidtke, Jessica G Moreland, Marko Z Radic, Caroline N Jones

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Lab on a chip, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Leveraging Microphysiological Systems to Facilitate Neutrophil-Based Cancer Immunotherapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  2. Article
  3. Frontiers in immunology · 2026
    Article
  4. Review
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Udaya Sree DatlaTranslational Biology, Medicine and Health, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA.ORCID 0000-0001-7224-0714
Bhaskar VundurthyRobotics Institute, Carnegie Mellon University, Pittsburgh, PA, USA.ORCID 0000-0002-6876-4424
Jessica S HookDepartment of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Nidhi MenonTranslational Biology, Medicine and Health, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA.
Hossein Razmi BagtashDepartment of Bioengineering, University of Texas at Dallas, Richardson, TX, USA. Caroline.jones@utdallas.edu.
Tarik ShihabeddinDepartment of Bioengineering, University of Texas at Dallas, Richardson, TX, USA. Caroline.jones@utdallas.edu.
David W SchmidtkeDepartment of Bioengineering, University of Texas at Dallas, Richardson, TX, USA. Caroline.jones@utdallas.edu.
Jessica G MorelandDepartment of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Marko Z RadicDepartment of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis, TN, USA.ORCID 0000-0002-8004-282X
Caroline N JonesDepartment of Bioengineering, University of Texas at Dallas, Richardson, TX, USA. Caroline.jones@utdallas.edu.ORCID 0000-0001-6003-9335
The University of Texas at Dallas · USThe University of Texas Southwestern Medical Center · USCarnegie Mellon University · USUniversity of Tennessee Health Science Center · USVirginia Tech · US

Funding

Microsystems to Decipher Leukocyte Decision-MakingR35GM133610 · NIGMS · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI JONES, CAROLINE N. · 2019 to 2023
$1.8M
NIGMS NIH HHS R35 GM133610
6 · The paper itself

Abstract

Excessive release of neutrophil extracellular traps (NETs) has been reported in various human pathologies, including COVID-19 patients. Elevated NET levels serve as a biomarker, indicating increased coagulopathy and immunothrombosis risks in these patients. Traditional immunoassays employed to quantify NET release focus on bulk measurements of released chromatin in simplified microenvironments. In this study, we fabricated a novel NET-array device to quantify NET release from primary human neutrophils with single-cell resolution in the presence of the motile bacteria

Indexed as

Extracellular TrapsHistonesHumansInflammationInflammation MediatorsNeutrophilsHistonesInflammation Mediators

Identifiers

PMID38189525
PMCPMC10826461
OpenAlexW4390596857

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.