Evidence map›Paper›PMID 38189296›Full record

ArticleMicrobiology spectrum2024

Bacterial pathogens in Xpert MTB/RIF Ultra-negative sputum samples of patients with presumptive tuberculosis in a high TB burden setting: a 16S rRNA analysis.

Wakjira Kebede, Gemeda Abebe, Ilke De Boeck, Esayas Kebede Gudina, Eline Cauwenberghs, Sarah Lebeer, Annelies Van Rie

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiology spectrum, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Mechanisms ofBreathe (Sheffield, England) · 2026
    Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Wakjira KebedeDepartment of Epidemiology and Social Medicine, Faculty of Medicine and Health sciences, University of Antwerp, Antwerp, Belgium.ORCID 0000-0001-5241-4019
Gemeda AbebeMycobacteriology Research Center, Jimma University, Jimma, Ethiopia.
Ilke De BoeckDepartment of Bioscience Engineering, University of Antwerp, Antwerp, Belgium.
Esayas Kebede GudinaDepartment of Internal Medicine, Jimma University Medical Center, Jimma University, Jimma, Ethiopia.
Eline CauwenberghsDepartment of Bioscience Engineering, University of Antwerp, Antwerp, Belgium.
Sarah LebeerDepartment of Bioscience Engineering, University of Antwerp, Antwerp, Belgium.ORCID 0000-0002-9400-6918
Annelies Van RieDepartment of Epidemiology and Social Medicine, Faculty of Medicine and Health sciences, University of Antwerp, Antwerp, Belgium.
University of Antwerp · BEJimma University · ET

Funding

VLIRUOS (VLIR-UOS) VLIR-OUS network
6 · The paper itself

Abstract

In patients with presumptive tuberculosis (TB) in whom the diagnosis of TB was excluded, understanding the bacterial etiology of lower respiratory tract infections (LRTIs) is important for optimal patient management. A secondary analysis was performed on a cohort of 250 hospitalized patients with symptoms of TB. Bacterial DNA was extracted from sputum samples for Illumina 16S rRNA sequencing to identify bacterial species based on amplicon sequence variant level. The bacterial pathogen most likely to be responsible for the patients' LRTI could only be identified in a minority (6.0%, 13/215) of cases based on 16S rRNA amplicon sequencing:

Indexed as

Mycobacterium tuberculosisRespiratory Tract InfectionsTuberculosisTuberculosis, PulmonaryHumansRifampinRNA, Ribosomal, 16SSensitivity and SpecificitySputumRifampinRNA, Ribosomal, 16Sbacterial etiologydiagnosticsEthiopiaLRTIsM. tuberculosispresumptive TB casessequencing

Identifiers

PMID38189296
PMCPMC10845949
OpenAlexW4390671859

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.