Evidence map›Paper›PMID 38189139›Full record

SynthesisHypertension (Dallas, Tex. : 1979)2024

Self-Measured Blood Pressure-Guided Pharmacotherapy: A Systematic Review and Meta-Analysis of United States-Based Telemedicine Trials.

Sameer Acharya, Gagan Neupane, Austin Seals, Madhav Kc, Dean Giustini, Sharan Sharma, Yhenneko J Taylor, Deepak Palakshappa, Jeff D Williamson, Justin B Moore and 2 more

Open access · greenAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Hypertension (Dallas, Tex. : 1979), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
8.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Article
  5. Review
  6. Observational
  7. Article
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 8 institutions in 2 countries.

Sameer AcharyaDepartment of Internal Medicine, Cayuga Medical Center, Ithaca, NY (S.A.).ORCID 0000-0003-3134-5055
Gagan NeupaneDepartment of Internal Medicine, Florida Atlantic University, Boca Raton (G.N.).ORCID 0000-0002-8194-7794
Austin Seals
Madhav KcSchool of Medicine, Yale University, New Haven, CT (M.K.).
Dean GiustiniThe University of British Columbia, Vancouver, Canada (D.G.).ORCID 0000-0002-6197-8788
Sharan SharmaSCL Health Heart and Vascular: Sisters of Charity of Leavenworth Health Heart and Vascular Institute, Brighton, CO (S.S.).
Yhenneko J TaylorCenter for Health System Sciences, Atrium Health, Charlotte, NC (Y.J.T., Y.P.).ORCID 0000-0002-5336-5666
Deepak PalakshappaDepartment of Internal Medicine, Atrium Health Wake Forest Baptist, Winston-Salem, NC (A.S., D.P., J.D.W., Y.P.).ORCID 0000-0003-1467-4965
Jeff D WilliamsonDepartment of Internal Medicine, Atrium Health Wake Forest Baptist, Winston-Salem, NC (A.S., D.P., J.D.W., Y.P.).
Justin B MooreDepartment of Implementation Science, Wake Forest University School of Medicine, Winston-Salem, NC (J.B.M.).ORCID 0000-0003-4059-0538
Hayden B BosworthDepartment of Population Health Sciences, Duke University, Durham, NC (H.B.B.).ORCID 0000-0001-6188-9825
Yashashwi PokharelDepartment of Internal Medicine, Atrium Health Wake Forest Baptist, Winston-Salem, NC (A.S., D.P., J.D.W., Y.P.).ORCID 0000-0002-9338-2073
Atrium Health Wake Forest Baptist · USAtrium Medical Cente · USDuke University · USFlorida Atlantic University · USSisters of Charity Health System · USUniversity of British Columbia · CAWake Forest University · USYale University · US

Funding

Mobile Technology for Primary Care to Address Food Insecurity and Improve Cardiovascular HealthK23HL146902 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI PALAKSHAPPA, DEEPAK · 2020 to 2024
$776k
NHLBI NIH HHS K23 HL146902
6 · The paper itself

Abstract

backgroundThe optimal approach to implementing telemedicine hypertension management in the United States is unknown.

methodsWe examined telemedicine hypertension management versus the effect of usual clinic-based care on blood pressure (BP) and patient/clinician-related heterogeneity in a systematic review/meta-analysis. We searched United States-based randomized trials from Medline, Embase, CENTRAL, CINAHL, PsycINFO, Compendex, Web of Science Core Collection, Scopus, and 2 trial registries. We used trial-level differences in BP and its control rate at ≥6 months using random-effects models. We examined heterogeneity in univariable metaregression and in prespecified subgroups (clinicians leading pharmacotherapy [physician/nonphysician], self-management support [pharmacist/nurse], White versus non-White patient predominant trials [>50% patients/trial], diabetes predominant trials [≥25% patients/trial], and White patient predominant but not diabetes predominant trials versus both non-White and diabetes patient predominant trials].

resultsThirteen, 11, and 7 trials were eligible for systolic and diastolic BP difference and BP control, respectively. Differences in systolic and diastolic BP and BP control rate were -7.3 mm Hg (95% CI, -9.4 to -5.2), -2.7 mm Hg (-4.0 to -1.5), and 10.1% (0.4%-19.9%), respectively, favoring telemedicine. Greater BP reduction occurred in trials where nonphysicians led pharmacotherapy, pharmacists provided self-management support, White patient predominant trials, and White patient predominant but not diabetes predominant trials, with no difference by diabetes predominant trials.

conclusionsTelemedicine hypertension management is more effective than clinic-based care in the United States, particularly when nonphysicians lead pharmacotherapy and pharmacists provide self-management support. Non-White patient predominant trials achieved less BP reduction. Equity-conscious, locally informed adaptation of telemedicine interventions is needed before wider implementation.

Indexed as

Antihypertensive AgentsHypertensionTelemedicineBlood PressureBlood Pressure Monitoring, AmbulatoryHumansRandomized Controlled Trials as TopicUnited StatesAntihypertensive Agentsadultblood pressurehumansself-managementUnited States

Identifiers

PMID38189139
PMCPMC11213974
OpenAlexW4390669501

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.