ArticleFrontiers in endocrinology2023
Causal association of immune cells and polycystic ovarian syndrome: a Mendelian randomization study.
Article in Frontiers in endocrinology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Antinuclear Antibodies in Polycystic Ovary Syndrome: A Systematic Review of Observational Studies.International journal of molecular sciences · 2025Pooled it
- Article
- Integrative Mendelian Randomization and Whole-Blood Transcriptomic Analysis Implicate a Myeloid-Inflammation Axis in Polycystic Ovary Syndrome.International journal of women's health · 2026Article
- Causal association between immune cytokines and psoriasis: A two-way Mendelian randomization study.Medicine · 2025Article
- Causal role of immune cells in primary liver cancer: a mendelian randomization study.BMC cancer · 2025Article
- Polycystic ovary syndrome and epithelial-mesenchymal transition: Mendelian randomization and single-cell analysis insights.Journal of ovarian research · 2025Article
- Dissecting Causal Relationships Between Immune Cells, Plasma Metabolites, and PCOS: Evidence From Mediating Mendelian Randomization Analysis.International journal of women's health · 2025Article
- Assessing the Causal Relationship Between Various Immune Cells and Attention Deficit Hyperactivity Disorder: Mendelian Randomization Study.Brain and behavior · 2025Article
- The relationship between polycystic ovary syndrome and gynecological cancers: neurotransmitter metabolism changes and immune regulation.Frontiers in immunology · 2025Review
- [Immunological status in patients with amenorrhea (literature review)].Problemy endokrinologii · 2024Review
- From proteome to pathogenesis: investigating polycystic ovary syndrome with Mendelian randomization analysis.Frontiers in endocrinology · 2024Article
- Leveraging genetics to investigate causal effects of immune cell phenotypes in periodontitis: a mendelian randomization study.Frontiers in genetics · 2024Article
- Causal role of immune cells in bipolar disorder: a Mendelian randomization study.Frontiers in psychiatry · 2024Article
- Unveiling the molecular landscape of PCOS: identifying hub genes and causal relationships through bioinformatics and Mendelian randomization.Frontiers in endocrinology · 2024Article
- Causal effects and metabolites mediators between immune cell and risk of breast cancer: a Mendelian randomization study.Frontiers in genetics · 2024Article
- Article
Corrections and comments
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4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Background: Polycystic ovarian syndrome (PCOS) is a common reproductive disorder that affects a considerable number of women worldwide. It is accompanied by irregular menstruation, hyperandrogenism, metabolic abnormalities, reproductive disorders and other clinical symptoms, which seriously endangers women's physical and mental health. The etiology and pathogenesis of PCOS are not completely clear, but it is hypothesized that immune system may play a key role in it. However, previous studies investigating the connection between immune cells and PCOS have produced conflicting results. Methods: Mendelian randomization (MR) is a powerful study design that uses genetic variants as instrumental variables to enable examination of the causal effect of an exposure on an outcome in observational data. In this study, we utilized a comprehensive two-sample MR analysis to examine the causal link between 731 immune cells and PCOS. We employed complementary MR methods, such as the inverse-variance weighted (IVW) method, and conducted sensitivity analyses to evaluate the reliability of the outcomes. Results: Four immunophenotypes were identified to be significantly associated with PCOS risk: Memory B cell AC (IVW: OR [95%]: 1.123[1.040 to 1.213], Conclusions: Our MR analysis provides strong evidence supporting a causal association between immune cells and the susceptibility of PCOS. This discovery can assist in clinical decision-making regarding disease prognosis and treatment options, and also provides a new direction for drug development.
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