Evidence map›Paper›PMID 38188977›Full record

ArticleAnnals of vascular diseases2023

Intraoperative Heparin Resistance after Administration of Andexanet Alfa to Manage an Internal Iliac Artery Aneurysm Rupture: A Case Report.

Kanetsugu Nagao, Shigeyuki Yamashita, Rina Ebe, Norihito Naruto, Hisakatsu Ito, Saori Nagura, Toshio Doi, Kazuaki Fukahara, Naoki Yoshimura

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of vascular diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 72% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Kanetsugu NagaoFirst Department of Surgery, University of Toyama, Toyama, Toyama, Japan.
Shigeyuki YamashitaFirst Department of Surgery, University of Toyama, Toyama, Toyama, Japan.
Rina EbeFirst Department of Surgery, University of Toyama, Toyama, Toyama, Japan.
Norihito NarutoDepartment of Radiology, University of Toyama, Toyama, Toyama, Japan.
Hisakatsu ItoDepartment of Anesthesia, University of Toyama, Toyama, Toyama, Japan.
Saori NaguraFirst Department of Surgery, University of Toyama, Toyama, Toyama, Japan.
Toshio DoiFirst Department of Surgery, University of Toyama, Toyama, Toyama, Japan.
Kazuaki FukaharaFirst Department of Surgery, University of Toyama, Toyama, Toyama, Japan.
Naoki YoshimuraFirst Department of Surgery, University of Toyama, Toyama, Toyama, Japan.
University of Toyama · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antithrombotic agents are increasingly prescribed to older adults; however, they are associated with bleeding-related complications. We describe a case of intraoperative heparin resistance after administration of andexanet alfa (AA). An 81-year-old man was diagnosed with a ruptured internal iliac artery aneurysm. The patient required emergency endovascular aneurysm repair and was treated with AA because he was receiving apixaban. Despite high-dose intraoperative heparin administration, his activated coagulation time was not prolonged. Our findings suggest that AA should be administered with caution in patients experiencing potentially fatal bleeding (requiring surgical intervention) who are also receiving direct oral anticoagulants.

Indexed as

andexanet alfaendovascular aneurysm repairheparin resistance

Identifiers

PMID38188977
PMCPMC10766740
OpenAlexW4387483201

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.