ArticleFrontiers in pediatrics2023
Association between mortality and critical events within 48 hours of transfer to the pediatric intensive care unit.
Article in Frontiers in pediatrics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Mortality risk prediction from dense PICU data from patients with suspected infection: data-derived physiological trajectories outperform expert assessments when temporal resolution is high.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2026Article
- Machine Learning for Predicting Critical Events Among Hospitalized Children.JAMA network open · 2025Article
- Machine Learning-Based Pediatric Early Warning Score: Patient Outcomes in a Pre- Versus Post-Implementation Study, 2019-2023.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2025Article
- Rural-Urban Disparities in Hospital Services and Outcomes for Children With Medical Complexity.JAMA network open · 2024Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Introduction: Critical deterioration in hospitalized children, defined as ward to pediatric intensive care unit (PICU) transfer followed by mechanical ventilation (MV) or vasoactive infusion (VI) within 12 h, has been used as a primary metric to evaluate the effectiveness of clinical interventions or quality improvement initiatives. We explore the association between critical events (CEs), i.e., MV or VI events, within the first 48 h of PICU transfer from the ward or emergency department (ED) and in-hospital mortality. Methods: We conducted a retrospective study of a cohort of PICU transfers from the ward or the ED at two tertiary-care academic hospitals. We determined the association between mortality and occurrence of CEs within 48 h of PICU transfer after adjusting for age, gender, hospital, and prior comorbidities. Results: Experiencing a CE within 48 h of PICU transfer was associated with an increased risk of mortality [OR 12.40 (95% CI: 8.12-19.23, Discussion: We demonstrate that occurrence of a CE within 48 h of PICU transfer was associated with mortality after adjusting for confounders. Studies focusing on the impact of quality improvement efforts may benefit from using CEs within 48 h of PICU transfer as an additional evaluation metric, provided these events could have been influenced by the initiative.
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Registered trials
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