Evidence map›Paper›PMID 38188683›Full record

ReviewOncology research2023

Application of exosomal miRNA mediated macrophage polarization in colorectal cancer: Current progress and challenges.

Yun Zhang, Shaling Tang, Yubo Gao, Zhongting Lu, Yuan Yang, Jing Chen, Tao Li

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Oncology research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Yun ZhangDepartment of Oncology, School of Clinical Medicine, Ningxia Medical University, Yinchuan, China.
Shaling TangDepartment of Oncology, School of Clinical Medicine, Ningxia Medical University, Yinchuan, China.
Yubo GaoDepartment of Oncology, School of Clinical Medicine, Ningxia Medical University, Yinchuan, China.
Zhongting LuDepartment of Oncology, School of Clinical Medicine, Ningxia Medical University, Yinchuan, China.
Yuan YangDepartment of Oncology, School of Clinical Medicine, Ningxia Medical University, Yinchuan, China.
Jing ChenSchool of Basic Medical Sciences, Ningxia Medical University, Yinchuan, China.
Tao LiDepartment of Surgical Oncology, Tumor Hospital, The General Hospital of Ningxia Medical University, Yinchuan, China.
Ningxia Medical University General Hospital · CNNingxia Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Colorectal cancer (CRC) is a major global health problem with high morbidity and mortality rates. Surgical resection is the main treatment for early-stage CRC, but detecting it early is challenging. Therefore, effective therapeutic targets for advanced patients are still lacking. Exosomes, tiny vesicles in body fluids, play a crucial role in tumor metastasis, immune regulation, and drug resistance. Interestingly, they can even serve as a biomarker for cancer diagnosis and prognosis. Studies have shown that exosomes can carry miRNA, mediate the polarization of M1/M2 macrophages, promote the proliferation and metastasis of cancer cells, and affect the prognosis of CRC. Since the gastrointestinal tract has many macrophages, understanding the mechanism behind exosomal miRNA-mediated macrophage polarization in CRC treatment is crucial. This article summarizes recent advancements in the study of exosomal miRNAs in CRC and their potential as diagnostic and prognostic markers.

Indexed as

Colorectal NeoplasmsExosomesMicroRNAsHumansMacrophagesMicroRNAsColorectal cancerExosomesMacrophagesmicroRNATreatment

Identifiers

PMID38188683
PMCPMC10767244
OpenAlexW4388712524

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.