Evidence map›Paper›PMID 38188566›Full record

ArticleFrontiers in microbiology2023

The domestication of SARS-CoV-2 into a seasonal infection by viral variants.

Ryley D McClelland, Yi-Chan James Lin, Tyce N Culp, Ryan Noyce, David Evans, Tom C Hobman, Vanessa Meier-Stephenson, David J Marchant

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. A20 as a Potential Therapeutic Target for COVID-19.Immunity, inflammation and disease · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ryley D McClellandDepartment of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB, Canada.
Yi-Chan James LinDepartment of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB, Canada.
Tyce N CulpDepartment of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB, Canada.
Ryan NoyceDepartment of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB, Canada.
David EvansDepartment of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB, Canada.
Tom C HobmanDepartment of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB, Canada.
Vanessa Meier-StephensonDepartment of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB, Canada.
David J MarchantDepartment of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The COVID-19 pandemic was caused by the zoonotic betacoronavirus SARS-CoV-2. SARS-CoV-2 variants have emerged due to adaptation in humans, shifting SARS-CoV-2 towards an endemic seasonal virus. We have termed this process 'virus domestication'. Methods: We analyzed aggregate COVID-19 data from a publicly funded healthcare system in Canada from March 7, 2020 to November 21, 2022. We graphed surrogate calculations of COVID-19 disease severity and SARS-CoV-2 variant plaque sizes in tissue culture. Results and Discussion: Mutations in SARS-CoV-2 adapt the virus to better infect humans and evade the host immune response, resulting in the emergence of variants with altered pathogenicity. We observed a decrease in COVID-19 disease severity surrogates after the arrival of the Delta variant, coinciding with significantly smaller plaque sizes. Overall, we suggest that SARS-CoV-2 has become more infectious and less virulent through viral domestication. Our findings highlight the importance of SARS-CoV-2 vaccination and help inform public policy on the highest probability outcomes during viral pandemics.

Indexed as

adaptationcoronavirusCOVID19SARSseasonal infectionsurrogatesvirus

Identifiers

PMID38188566
PMCPMC10769486

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.