Evidence map›Paper›PMID 38188369›Full record

ArticleEuropean journal of organic chemistry2023

A Building Block Approach for the Total Synthesis of YM-385781.

Yu Zhu, Siyue Liu, Johnny Zigmond, Kevin M Kaltenbronn, Kendall J Blumer, Kevin D Moeller

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of organic chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yu ZhuDepartment of Chemistry, Washington University, St. Louis, MO 63130.
Siyue LiuDepartment of Chemistry, Washington University, St. Louis, MO 63130.
Johnny ZigmondDepartment of Chemistry, Washington University, St. Louis, MO 63130.
Kevin M KaltenbronnDepartment of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO.
Kendall J BlumerDepartment of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO.
Kevin D MoellerDepartment of Chemistry, Washington University, St. Louis, MO 63130.

Funding

PHARMACOLOGICAL TARGETING OF GALPHA SUBUNITS IN DISEASER01GM124093 · NIGMS · WASHINGTON UNIVERSITY · PI BLUMER, KENDALL J, MOELLER, KEVIN DAVID · 2017 to 2024
$3.6M
NIGMS NIH HHS R01 GM124093
6 · The paper itself

Abstract

YM-254890 and FR900359 are potent and selective inhibitors of the Gq/11-signaling pathway. As such, they have been attractive targets for both synthesis and biological studies. Yet in spite of this effort, a versatile synthetic approach to the molecules that allows for the rapid construction of a variety of non-natural and labelled analogs and an increase in the amount of those analogs available remains elusive. We report here a convergent building block approach to the molecules that can solve this challenge.

Indexed as

Cyclic Peptide SynthesisInhibitorsYM-analogs

Identifiers

PMID38188369
PMCPMC10766104

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.