Evidence map›Paper›PMID 38188286›Full record

ArticleFrontiers in oncology2023

Metabolic pseudoprogression in a patient with metastatic KIT exon 11 GIST after 1 month of first-line imatinib: a case report.

Elisa Tassinari, Nicole Conci, Giacomo Battisti, Francesco Porta, Valerio Di Scioscio, Maria Giulia Pirini, Dario de Biase, Maria Concetta Nigro, Miriam Iezza, Fausto Castagnetti and 4 more

Open access · goldAbstract readCase Reports
In one paragraph

Article in Frontiers in oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Elisa Tassinari *Department of Medical and Surgical Sciences (DIMEC), University of Bologna, Bologna, Italy.
Nicole Conci *Department of Medical and Surgical Sciences (DIMEC), University of Bologna, Bologna, Italy.
Giacomo BattistiNuclear Medicine, IRCCS Azienda Ospedaliero-Universitaria di Bologna-Policlinico di Sant'Orsola, Bologna, Italy.
Francesco PortaDepartment of Pediatric and Adult Cardio-Thoracovascular, Oncoematologic and Emergencies Radiology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
Valerio Di ScioscioDepartment of Pediatric and Adult Cardio-Thoracovascular, Oncoematologic and Emergencies Radiology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
Maria Giulia PiriniPathology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna-Policlinico di Sant'Orsola, Bologna, Italy.
Dario de BiaseDepartment of Pharmacy and Biotechnology (FaBit), University of Bologna, Bologna, Italy.
Maria Concetta NigroDepartment of Medical and Surgical Sciences (DIMEC), University of Bologna, Bologna, Italy.
Miriam IezzaDepartment of Medical and Surgical Sciences (DIMEC), University of Bologna, Bologna, Italy.
Fausto CastagnettiDepartment of Medical and Surgical Sciences (DIMEC), University of Bologna, Bologna, Italy.
Luigi LovatoDepartment of Pediatric and Adult Cardio-Thoracovascular, Oncoematologic and Emergencies Radiology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
Stefano FantiNuclear Medicine, IRCCS Azienda Ospedaliero-Universitaria di Bologna-Policlinico di Sant'Orsola, Bologna, Italy.
Maria Abbondanza PantaleoDepartment of Medical and Surgical Sciences (DIMEC), University of Bologna, Bologna, Italy.
Margherita NanniniDepartment of Medical and Surgical Sciences (DIMEC), University of Bologna, Bologna, Italy.
Azienda USL di Bologna · ITUniversity of Bologna · ITIRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Positron emission tomography (PET) with 18-fluorodeoxyglucose ( Case presentation: Herein, we described in detail a case of an exon 11 KIT mutated-metastatic GIST patient, who presented an unexpected metabolic progression at the early Conclusions: This report aims to highlight the existence of this metabolic pseudoprogression in GIST at the beginning of imatinib therapy in order to avoid early treatment discontinuation. Therefore, an early metabolic progression during a molecular targeted therapy always deserves to be evaluated in the context of the disease molecular profiling, and in case of a discordant finding between functional imaging and molecular background, a short-term longitudinal control should be suggested.

Indexed as

FDG-PETfunctional imaginggastrointestinal stromal tumorsGISTimatinib

Identifiers

PMID38188286
PMCPMC10769864
OpenAlexW4390005138

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.