ArticleThe Lancet regional health. Europe2024
Prevention of incisional hernia with prophylactic onlay and sublay mesh reinforcement vs. primary suture only in midline laparotomies (PRIMA): long-term outcomes of a multicentre, double-blind, randomised controlled trial.
Article in The Lancet regional health. Europe, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06762561 (Prophylactic Mesh Reinforcement After Open Aortic Aneurysm Repair), which is not on this map. Cited by 19 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prophylactic Mesh Reinforcement After Open Aortic Aneurysm Repair: a Retrospective Study
Who cites it
19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 21 citations in OpenAlex.
- Prophylactic mesh reinforcement at emergency midline laparotomy: a systematic review and meta-analysis with pre-specified subgroup analysis of contaminated and dirty abdominal wounds (CDC Class III-IV).Hernia : the journal of hernias and abdominal wall surgery · 2026Pooled it
- Retromuscular prophylactic mesh reinforcement after midline laparotomy: a systematic review and meta-analysis.Hernia : the journal of hernias and abdominal wall surgery · 2025Pooled it
- Prophylactic mesh versus primary closure in emergency and elective surgeries: a systematic review and meta-analysis of randomized clinical trials.Hernia : the journal of hernias and abdominal wall surgery · 2024Pooled it
- Prophylactic Mesh-related Reoperations and Mesh-related Problems During Subsequent Relaparotomies: Long-term Results From the PRIMA Trial.Annals of surgery · 2026Trial
- Three-year follow-up analysis of the short-stitch versus long-stitch technique for elective midline abdominal closure randomized-controlled (ESTOIH) trial.Hernia : the journal of hernias and abdominal wall surgery · 2024Trial
- Genetic Susceptibility to Incisional Hernia Evaluation of Hernia Polygenic Risk Scores.medRxiv : the preprint server for health sciences · 2026Article
- Decoding the genetic architecture of hernia through genome-wide association and multi-trait analyses.medRxiv : the preprint server for health sciences · 2026Article
- Composition and influencing factors of hospitalization costs in adult patients undergoing incisional hernia repair surgery.Updates in surgery · 2026Article
- External validation of the Penn hernia risk calculator: an evaluation of model transportability for incisional hernia prediction in open pancreatic surgery.Hernia : the journal of hernias and abdominal wall surgery · 2026Article
- Suture Techniques and Materials for Fascial Closure of Abdominal Wall Incisions: A Comprehensive Meta-Analysis.Annals of surgery open : perspectives of surgical history, education, and clinical approaches · 2025Article
- Prophylactic mesh reinforcement after open aortic aneurysm repair: a prospective cohort study.Frontiers in surgery · 2025Article
- Long-Term Follow-Up of Prophylactic Mesh and Methodological Considerations.Journal of abdominal wall surgery : JAWS · 2025Article
- Early outcomes of robotic modified retromuscular Sugarbaker technique for end colostomy parastomal hernia repair.Hernia : the journal of hernias and abdominal wall surgery · 2024Article
- Occurrence and prevention of incisional hernia following laparoscopic colorectal surgery.World journal of gastrointestinal surgery · 2024Article
- Advances and Techniques in Subcuticular Suturing for Abdominal Wall Closure: A Comprehensive Review.Cureus · 2024Review
- Article
- [Incisional hernias: epidemiology, evidence and guidelines].Chirurgie (Heidelberg, Germany) · 2024Review
- Incisional Hernia Depends on More Than Just Mesh Placement.Journal of abdominal wall surgery : JAWS · 2024Article
- Prophylactic Mesh Augmentation of Midline Closure in Patients Undergoing Resection for Upper Gastrointestinal Cancer Reduces the Rate of Incisional Hernia: Results of a Case-Series Study.Journal of abdominal wall surgery : JAWS · 2024Article
Corrections and comments
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Authors and funding
15 authors at 9 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Incisional hernia occurs approximately in 40% of high-risk patients after midline laparotomy. Prophylactic mesh placement has shown promising results, but long-term outcomes are needed. The present study aimed to assess the long-term incisional hernia rates of the previously conducted PRIMA trial with radiological follow-up. Methods: In the PRIMA trial, patients with increased risk of incisional hernia formation (AAA or BMI ≥27 kg/m Findings: Between 2009 and 2012, 480 patients were randomized: 107 primary suture, 188 onlay mesh and 185 sublay mesh. Five-year incisional hernia rates were 53.4% (95% CI: 40.4-64.8), 24.7% (95% CI: 12.7-38.8), 29.8% (95% CI: 17.9-42.6), respectively. Compared to primary suture, onlay mesh (HR: 0.390, 95% CI: 0.248-0.614, p < 0.001) and sublay mesh (HR: 0.485, 95% CI: 0.309-0.761, p = 0.002) were associated with a significantly lower risk of incisional hernia development. Interpretation: Prophylactic mesh placement remained effective in reducing incisional hernia occurrence after midline laparotomy in high-risk patients during long-term follow-up. Hernia rates in the primary suture group were higher than previously anticipated. Funding: B. Braun.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.