Evidence map›Paper›PMID 38188257›Full record

ArticleFrontiers in cardiovascular medicine2023

Metabolic status differentiates Trp53inp2 function in pressure-overload induced heart failure.

Jianfang Liu, Tian Liu, Shuxun Vincent Ren, Cansheng Zhu, Eyad Bouso, Samir Mamlouk, Christoph D Rau, Yibin Wang, Chen Gao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cardiovascular medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Jianfang Liu *Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China.
Tian Liu *Department of Pharmacology and Systems Physiology, University of Cincinnati, Cincinnati, OH, United States.
Shuxun Vincent RenSignature Research Program in Cardiovascular and Metabolic Diseases, DukeNUS Medical School, Singapore, Singapore.
Cansheng ZhuDepartment of Pharmacology and Systems Physiology, University of Cincinnati, Cincinnati, OH, United States.
Eyad BousoDepartment of Pharmacology and Systems Physiology, University of Cincinnati, Cincinnati, OH, United States.
Samir MamloukDepartment of Pharmacology and Systems Physiology, University of Cincinnati, Cincinnati, OH, United States.
Christoph D RauDepartment of Genetics, School of Medicine, University of North Carolina, Chapel Hill, NC, United States.
Yibin WangSignature Research Program in Cardiovascular and Metabolic Diseases, DukeNUS Medical School, Singapore, Singapore.
Chen GaoDepartment of Pharmacology and Systems Physiology, University of Cincinnati, Cincinnati, OH, United States.
University of Cincinnati · USSignature Research (United States) · USUniversity of North Carolina at Chapel Hill · USWuhan University · CN

Funding

Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Andrea L Hevener · 2003 to 2026
$40.4M
Discovery of Novel Epigenetic Regulators of Heart Failure in a Panel of MiceR00HL138301 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI RAU, CHRISTOPH DANIEL · 2020 to 2022
$747k
Novel Mechanism of RBFox1 Mediated RNA Metabolism in Heart FailureR00HL141626 · NHLBI · UNIVERSITY OF CINCINNATI · PI GAO, CHEN · 2022 to 2024
$747k
NHLBI NIH HHS R00 HL138301NHLBI NIH HHS R00 HL141626NIDDK NIH HHS P30 DK063491
6 · The paper itself

Abstract

Cardiometabolic disorders encompass a broad range of cardiovascular complications associated with metabolic dysfunction. These conditions have an increasing share in the health burden worldwide due to worsening endemic of hypertension, obesity, and diabetes. Previous studies have identified Tumor Protein p53-inducible Nuclear Protein 2 (Trp53inp2) as a molecular link between hyperglycemia and cardiac hypertrophy. However, its role in cardiac pathology has never been determined

Indexed as

cardiometabolic syndromeglucose metabolismheart failuretranscription factorTrp53inp2

Identifiers

PMID38188257
PMCPMC10766701
OpenAlexW4389919496

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.