Evidence map›Paper›PMID 38188073›Full record

ArticleJournal of oral microbiology2024

Ultrasmall epibiont

Erik L Hendrickson, Batbileg Bor, Kristopher A Kerns, Lujia Cen, Wenyuan Shi, Xuesong He, Jeffrey S McLean

Open access · goldAbstract read
In one paragraph

Article in Journal of oral microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Identifying essential genes inJournal of bacteriology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Erik L HendricksonDepartment of Periodontics, University of Washington, Seattle, WA, USA.
Batbileg BorDepartment of Microbiology, The Forsyth Institute, Cambridge, MA, USA.
Kristopher A KernsDepartment of Periodontics, University of Washington, Seattle, WA, USA.
Lujia CenDepartment of Microbiology, The Forsyth Institute, Cambridge, MA, USA.
Wenyuan ShiDepartment of Microbiology, The Forsyth Institute, Cambridge, MA, USA.
Xuesong HeDepartment of Microbiology, The Forsyth Institute, Cambridge, MA, USA.
Jeffrey S McLeanDepartment of Periodontics, University of Washington, Seattle, WA, USA.
University of Washington · USHarvard University · US

Funding

Institute of Translational Health SciencesKL2TR000421 · NCATS · UNIVERSITY OF WASHINGTON · PI DISIS, MARY L. · 2012 to 2016
$12.6M
Domestication and characterization of TM7-the most elusive oral phylumR01DE023810 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Xuesong He, Jeffrey Scott McLean · 2014 to 2026
$6.6M
Impact of Saccharibacteria and their bacterial hosts in Periodontal and Inflammatory DiseasesR01DE031274 · NIDCR · ADA FORSYTH INSTITUTE, INC. · PI Batbileg Bor · 2022 to 2026
$2.5M
Resolving Oral Bacteria Interactions with a High-Throughput Low-Cost Single-Cell Transcriptomics ApproachR21DE032890 · NIDCR · UNIVERSITY OF WASHINGTON · PI KUCHINA, ANNA, MCLEAN, JEFFREY SCOTT · 2023 to 2024
$485k
Molecular and pathogenic study of an oral TM7 strain, the first cultivated ultra-small bacteriumK99DE027719 · NIDCR · ADA FORSYTH INSTITUTE, INC. · PI BOR, BATBILEG · 2018 to 2019
$268k
NCATS NIH HHS KL2 TR000421NIDCR NIH HHS K99 DE027719NIDCR NIH HHS R01 DE023810NIDCR NIH HHS R01 DE031274NIDCR NIH HHS R21 DE032890
6 · The paper itself

Abstract

Background: Oral Saccharibacteria Results: Transcriptomes of TM7× and host, XH001, were captured during the recovery phase and compared to uninfected host and the early host/epibiont interaction (initial encounter). XH001 showed increased expression for rhamnose cell wall components and for the precursor to peptidoglycan while TM7× showed increases in the peptidoglycan pathway. Transporter expression was generally increased for both organisms during recovery compared to the initial encounter, though, XH001 showed lower amino acid transporter expression. Consistent with host parasitism, XH001 showed increased expression of various stress-related genes during recovery while TM7× showed reduced stress. TM7× displayed higher expression of type IV pili, consistent with increased attachment to new hosts. Conclusion: As TM7× is a member of the broadly distributed Candidate Phyla Radiation with small genomes lacking numerous biosynthetic pathways, this study provides further insights into how these epibionts interact and modulate their host bacteria.

Indexed as

epibiontoralparasitismRNAseqSaccharibacteriaTranscriptome

Identifiers

PMID38188073
PMCPMC10768705
OpenAlexW4389160600

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.