Evidence map›Paper›PMID 38187761›Full record

ArticlebioRxiv : the preprint server for biology2023

Identification of new ciliary signaling pathways in the brain and insights into neurological disorders.

Abdelhalim Loukil, Emma Ebright, Akiyoshi Uezu, Yudong Gao, Scott H Soderling, Sarah C Goetz

Open access · greenAbstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 9 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Abdelhalim LoukilPediatrics and Rare Diseases Group, Sanford Research, Sioux Falls, SD 57104, USA.ORCID 0000-0002-5051-2800
Emma EbrightDepartment of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC 27710, USA.
Akiyoshi UezuDepartment of Cell Biology, Duke University Medical School, Durham, NC 27710, USA.
Yudong GaoDepartment of Cell Biology, Duke University Medical School, Durham, NC 27710, USA.
Scott H SoderlingDepartment of Cell Biology, Duke University Medical School, Durham, NC 27710, USA.
Sarah C GoetzDepartment of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC 27710, USA.
Duke University · US

Funding

Identifying the molecular networks regulating cilium assembly and signalingR01HD099784 · NICHD · DUKE UNIVERSITY · PI GOETZ, SARAH · 2019 to 2023
$1.9M
Identifying regulatory networks that govern primary cilia remodeling and neural signalingR35GM151229 · NIGMS · SANFORD RESEARCH/USD · PI Abdelhalim Loukil · 2023 to 2026
$1.7M
Characterizing the role of TTBK proteins in ciliogenesis and neural functionR00HD076444 · NICHD · DUKE UNIVERSITY · PI GOETZ, SARAH · 2015 to 2017
$696k
NICHD NIH HHS R00 HD076444NICHD NIH HHS R01 HD099784NIGMS NIH HHS R35 GM151229
6 · The paper itself

Abstract

Primary cilia are conserved sensory hubs essential for signaling transduction and embryonic development. Ciliary dysfunction causes a variety of developmental syndromes with neurological features and cognitive impairment, whose basis mostly remains unknown. Despite connections to neural function, the primary cilium remains an overlooked organelle in the brain. Most neurons have a primary cilium; however, it is still unclear how this organelle modulates brain architecture and function, given the lack of any systemic dissection of neuronal ciliary signaling. Here, we present the first in vivo glance at the molecular composition of cilia in the mouse brain. We have adapted

Indexed as

Biological sciences/Cell biologyiBioIDmature brainneurodevelopmental disordersneuronsprimary cilia

Identifiers

PMID38187761
PMCPMC10769350
OpenAlexW4390048606

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.